U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Amy1 amylase 1, salivary [ Mus musculus (house mouse) ]

Gene ID: 11722, updated on 27-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Amy1provided by MGI
Official Full Name
amylase 1, salivaryprovided by MGI
Primary source
MGI:MGI:88019
See related
Ensembl:ENSMUSG00000074264 AllianceGenome:MGI:88019
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Amy-1; Amy1a; C030014B17Rik
Summary
Enables amylase activity. Acts upstream of or within response to bacterium. Located in extracellular space. Is expressed in several structures, including nervous system; pancreas; and submandibular gland. Orthologous to several human genes including AMY2A (amylase alpha 2A) and AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E18 (RPKM 29.9), CNS E18 (RPKM 24.2) and 17 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Amy1 in Genome Data Viewer
Location:
3 F3; 3 49.35 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (113349601..113371399, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (113555952..113577750, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene amylase 2a2 Neighboring gene amylase 2a1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:113308015-113308316 Neighboring gene RNA-binding region (RNP1, RRM) containing 3 Neighboring gene STARR-positive B cell enhancer mm9_chr3:113332370-113332671 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:113332840-113333141 Neighboring gene ribosomal protein L5 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The two promoters of the mouse alpha-amylase gene Amy-1a are differentially activated during parotid gland differentiation. Shaw P, et al. Cell, 1985 Apr. PMID 3872721
  2. Simultaneous expression of salivary and pancreatic amylase genes in cultured mouse hepatoma cells. Darlington GJ, et al. Mol Cell Biol, 1986 Apr. PMID 2431276, Free PMC Article
  3. A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs. Young RA, et al. Cell, 1981 Feb. PMID 6162570
  4. Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5' non-translated sequences. Hagenbüchle O, et al. Nature, 1981 Feb 19. PMID 6162108
  5. A salivary amylase transgene is efficiently expressed in liver but not in parotid gland of transgenic mice. Jones JM, et al. Nucleic Acids Res, 1989 Aug 25. PMID 2476716, Free PMC Article

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Not Applicable (5)  1 citation
  • Targeted (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-amylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-amylase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-amylase activity ISO
Inferred from Sequence Orthology
more info
  
enables amylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables chloride ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
alpha-amylase 1
Names
1,4-alpha-D-glucan glucanohydrolase 1
alpha-amylase amy1a
salivary and hepatic alpha-amylase
NP_001103975.1
NP_031472.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110505.1 → NP_001103975.1  alpha-amylase 1 precursor

    See identical proteins and their annotated locations for NP_001103975.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA616210, BB462169, CK791844, J00356, V00717, V00720
    Consensus CDS
    CCDS17776.1
    UniProtKB/Swiss-Prot
    P00687, Q921Y7
    Related
    ENSMUSP00000070368.6, ENSMUST00000067980.12
    Conserved Domains (3) summary
    cd11317
    Location:25 → 416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422 → 510
    Aamy_C; Aamy_C domain
    COG0366
    Location:46 → 315
    AmyA; Glycosidase [Carbohydrate transport and metabolism]

  2. NM_007446.2 → NP_031472.2  alpha-amylase 1 precursor

    See identical proteins and their annotated locations for NP_031472.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AA616210, BB462169, CK791844, J00356, V00717, V00719
    Consensus CDS
    CCDS17776.1
    UniProtKB/Swiss-Prot
    P00687, Q921Y7
    Related
    ENSMUSP00000102150.2, ENSMUST00000106540.8
    Conserved Domains (3) summary
    cd11317
    Location:25 → 416
    AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
    smart00632
    Location:422 → 510
    Aamy_C; Aamy_C domain
    COG0366
    Location:46 → 315
    AmyA; Glycosidase [Carbohydrate transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    113349601..113371399 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P00687.2 GenPept UniProtKB/Swiss-Prot:P00687

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools