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Ptpn12 protein tyrosine phosphatase, non-receptor type 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117255, updated on 4-Jan-2025

Summary

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Official Symbol
Ptpn12provided by RGD
Official Full Name
protein tyrosine phosphatase, non-receptor type 12provided by RGD
Primary source
RGD:620894
See related
EnsemblRapid:ENSRNOG00000013135 AllianceGenome:RGD:620894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ptpg1; RKPTP
Summary
Enables protein tyrosine phosphatase activity. Involved in tissue regeneration. Predicted to be located in cytosol and podosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 148.8), Spleen (RPKM 103.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ptpn12 in Genome Data Viewer
Location:
4q11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14913071..14985084)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (14020997..14092931)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10631129..10702390)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA40 Neighboring gene uncharacterized LOC102556034 Neighboring gene uncharacterized LOC120102213 Neighboring gene round spermatid basic protein 1-like Neighboring gene Alu-mediated CDKN1A/p21 transcriptional regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA cloning of a cytosolic protein tyrosine phosphatase (RKPTP) from rat kidney. Moriyama T, et al. FEBS Lett, 1994 Oct 24. PMID 7957881
  2. ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin. Gorostizaga AB, et al. J Cell Biochem, 2016 Sep. PMID 27061092
  3. Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners. Motohashi S, et al. Cell Immunol, 2014 May-Jun. PMID 24791697
  4. Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase. Charest A, et al. Biochem J, 1995 Jun 1. PMID 7772023, Free PMC Article
  5. Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas. Ceacareanu AC, et al. Am J Physiol Cell Physiol, 2006 Apr. PMID 16354758

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data demonstrate PTP-PEST expression in adrenal ZF and its regulation by ACTH/PKA and also suggest an ACTH-induced PTP-PEST-paxillin interaction
    Title: ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin.
  2. PTP-PEST is involved in the regulation of FcepsilonRI-mediated mast cell activation through at least two different processes represented by PTP activity-dependent and -independent pathways.
    Title: Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.
  3. Data suggest that IGF-I induces smooth muscle cell motility by increasing phosphotyrosine levels of p130(cas) and activating Rac1, and that nitric oxide decreases motility by activating PTP-PEST
    Title: Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AXY142 phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity, metal-dependent IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in tissue regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 12
NP_476456.2
XP_006235930.1
XP_006235932.1
XP_063141493.1
XP_063141494.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057115.2 → NP_476456.2  tyrosine-protein phosphatase non-receptor type 12

    See identical proteins and their annotated locations for NP_476456.2

    Status: VALIDATED

    Source sequence(s)
    BP489229, CK367675, CV102923, CX570435, D38072, DY560717
    UniProtKB/TrEMBL
    A0A8I5ZN71, A6K5C4, G3V7Q4
    Related
    ENSRNOP00000079518.1, ENSRNOT00000106350.2
    Conserved Domains (2) summary
    smart00194
    Location:28 → 292
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:60 → 292
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    14913071..14985084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235868.5 → XP_006235930.1  tyrosine-protein phosphatase non-receptor type 12 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN71
    Related
    ENSRNOP00000102951.1, ENSRNOT00000122000.1
    Conserved Domains (2) summary
    smart00194
    Location:28 → 292
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:60 → 292
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. XM_063285423.1 → XP_063141493.1  tyrosine-protein phosphatase non-receptor type 12 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZN71
    Related
    ENSRNOP00000017907.6, ENSRNOT00000017907.7

  3. XM_006235870.3 → XP_006235932.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZN71
    Conserved Domains (2) summary
    cd00047
    Location:1 → 173
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:1 → 173
    Y_phosphatase; Protein-tyrosine phosphatase

  4. XM_063285424.1 → XP_063141494.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZN71
    Related
    ENSRNOP00000111147.1, ENSRNOT00000126039.1
Nucleotide Protein Strain
Heading Accession and Version

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