St8sia2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: St8sia2provided by RGD
Official Full Name: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2provided by RGD
Primary source: RGD:621843
See related: EnsemblRapid:ENSRNOG00000065528 AllianceGenome:RGD:621843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: STX; Siat8b; SIAT8-B
Summary: Enables sialyltransferase activity. Involved in several processes, including neuron projection extension; positive regulation of synapse assembly; and response to cocaine. Located in perinuclear region of cytoplasm. Orthologous to human ST8SIA2 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Lung (RPKM 38.9), Testes (RPKM 32.7) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (137172354..137247796, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (127762573..127838017, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (135336374..135406699, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

After learning an olfactory discrimination task, no changes in STX gene expression level were observed in the olfactory bulb.
Title: Expression of polysialyltransferases (STX and PST) in adult rat olfactory bulb after an olfactory associative discrimination task.
Results suggest that sialyltransferase-X is probably involved in the proliferation of neural progenitor cells; polysialyltransferase may play a key role in synaptic plasticity of mature neural networks
Title: Dynamic expression of the polysialyltransferase in adult rat hippocampus performing an olfactory associative task.
ST8SiaII/STX expression is essential to allow a correct neuritic development at initial stages of hippocampus ontogeny
Title: Interfering polysialyltransferase ST8SiaII/STX mRNA inhibits neurite growth during early hippocampal development.

Submit: New GeneRIF Correction

General gene information

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Markers

Siat8b (e-PCR), detects polymorphism
- UniSTS:261921

STS-L29556 (e-PCR)
- UniSTS:73508

AU047261 (e-PCR)
- UniSTS:110683

AU047260 (e-PCR)
- UniSTS:110684

D1Bda26 (e-PCR)
- UniSTS:239773

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	ISO Inferred from Sequence Orthology more info
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables sialyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sialyltransferase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-glycan processing	ISO Inferred from Sequence Orthology more info
involved_in ganglioside biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligosaccharide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in sialylation	ISO Inferred from Sequence Orthology more info
involved_in sialylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-2,8-sialyltransferase 8B

Names: ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 2; ST8Sia II; ST8SiaII; sialyltransferase 8 (alpha-2, 8-sialyltransferase) B; sialyltransferase 8 (alpha-2, 8-sialytransferase) B; sialyltransferase 8B; sialyltransferase St8Sia II; sialyltransferase X; sialytransferase St8Sia II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.