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Gmpr guanosine monophosphate reductase [ Rattus norvegicus (Norway rat) ]

Gene ID: 117533, updated on 27-Nov-2024

Summary

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Official Symbol
Gmprprovided by RGD
Official Full Name
guanosine monophosphate reductaseprovided by RGD
Primary source
RGD:70980
See related
EnsemblRapid:ENSRNOG00000017250 AllianceGenome:RGD:70980
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gmpr1; GMPR 1
Summary
Predicted to enable GMP reductase activity. Predicted to be involved in purine nucleobase metabolic process and purine nucleotide metabolic process. Predicted to be part of GMP reductase complex. Orthologous to human GMPR (guanosine monophosphate reductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 574.3), Muscle (RPKM 561.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gmpr in Genome Data Viewer
Location:
17p14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (19357992..19395807, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (19151820..19189626, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (19543274..19580929, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene ataxin 1 Neighboring gene uncharacterized LOC120097815 Neighboring gene uncharacterized LOC120097816 Neighboring gene U6 spliceosomal RNA Neighboring gene myosin regulatory light chain interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure. Salvatore D, et al. J Biol Chem, 1998 Nov 20. PMID 9813009
  2. Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators. Spector T, et al. J Biol Chem, 1979 Apr 10. PMID 218932
  3. NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties. Deng Y, et al. Int J Biochem Cell Biol, 2002 Sep. PMID 12009299
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GMP reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables GMP reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in purine nucleobase metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GMP reductase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GMP reductase 1
Names
guanosine 5'-monophosphate oxidoreductase 1
guanosine monophosphate reductase 1
NP_476536.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057188.2 → NP_476536.2  GMP reductase 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q9Z244
    UniProtKB/TrEMBL
    F1LRV6
    Related
    ENSRNOP00000023613.3, ENSRNOT00000023613.6
    Conserved Domains (1) summary
    TIGR01305
    Location:3 → 344
    GMP_reduct_1; guanosine monophosphate reductase, eukaryotic

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    19357992..19395807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_010058805.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z244.1 GenPept UniProtKB/Swiss-Prot:Q9Z244

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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