Ppat phosphoribosyl pyrophosphate amidotransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppatprovided by RGD
Official Full Name: phosphoribosyl pyrophosphate amidotransferaseprovided by RGD
Primary source: RGD:620237
See related: EnsemblRapid:ENSRNOG00000002128 AllianceGenome:RGD:620237
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Atase
Summary: Enables amidophosphoribosyltransferase activity and identical protein binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; glutamine catabolic process; and lactation. Biomarker of hepatocellular carcinoma and renal cell carcinoma. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Muscle (RPKM 207.3), Heart (RPKM 207.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (31570010..31604410)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (31215741..31250144)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (33580541..33614919)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

PMC312758P2 (e-PCR)
- UniSTS:272913

RH141568 (e-PCR)
- UniSTS:223562

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables amidophosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables amidophosphoribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables amidophosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables amidophosphoribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' AMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' AMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 'de novo' IMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' IMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in 'de novo' XMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' XMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	IEP Inferred from Expression Pattern more info	PubMed
involved_in GMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GMP biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in glutamine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in purine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: amidophosphoribosyltransferase

Names: GPAT; glutamine phosphoribosylpyrophosphate amidotransferase

NP_476546.1

EC 2.4.2.14

XP_038947494.1

EC 2.4.2.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057198.2 → NP_476546.1 amidophosphoribosyltransferase

See identical proteins and their annotated locations for NP_476546.1

Status: PROVISIONAL

Source sequence(s)

BC086999

UniProtKB/Swiss-Prot

P35433

UniProtKB/TrEMBL

A6JCX0

Related

ENSRNOP00000106250.1, ENSRNOT00000169394.1

Conserved Domains (3) summary

cd06223
Location:306 → 442

PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

COG0034
Location:8 → 515

PurF; Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]

cd00715
Location:12 → 295

GPATase_N; Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the ...