ADD3 adducin 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADD3provided by HGNC
Official Full Name: adducin 3provided by HGNC
Primary source: HGNC:HGNC:245
See related: Ensembl:ENSG00000148700 MIM:601568; AllianceGenome:HGNC:245
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ADDL; CPSQ3
Summary: Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in brain (RPKM 57.5), thyroid (RPKM 50.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q25.1-q25.2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (109996373..110135565)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (110880187..111019428)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (111756131..111895323)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Contribution of ADD3 and the HLA Genes to Biliary Atresia Risk in Chinese.
Title: Contribution of ADD3 and the HLA Genes to Biliary Atresia Risk in Chinese.
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
Title: Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
The correlation between rs2501577 gene polymorphism and biliary atresia: a systematic review and meta-analysis.
Title: The correlation between rs2501577 gene polymorphism and biliary atresia: a systematic review and meta-analysis.
Posttranscriptional inhibition of gamma-adducin promotes the proliferation and migration of osteosarcoma cells.
Title: Posttranscriptional inhibition of γ-adducin promotes the proliferation and migration of osteosarcoma cells.
QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer.
Title: QKI-5 regulates the alternative splicing of cytoskeletal gene ADD3 in lung cancer.
Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis.
Title: Identification of New Genetic Clusters in Glioblastoma Multiforme: EGFR Status and ADD3 Losses Influence Prognosis.
Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility.
Title: Association of common variation in ADD3 and GPC1 with biliary atresia susceptibility.
Increased expression of phosphorylated adducin in tumor cells.
Title: Increased expression of phosphorylated adducin in tumor cells.
Loss of cytoskeleton protein ADD3 promotes tumor growth and angiogenesis in glioblastoma multiforme.
Title: Loss of cytoskeleton protein ADD3 promotes tumor growth and angiogenesis in glioblastoma multiforme.
The intragenic epistatic association of ADD3 with biliary atresia in Southern Han Chinese population has been reported.
Title: The intragenic epistatic association of ADD3 with biliary atresia in Southern Han Chinese population.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Cerebral palsy, spastic quadriplegic, 3 MedGen: C4310767 OMIM: 617008 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif downregulates the expression of adducin 3 protein gamma (ADD3) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44681 (e-PCR)
- UniSTS:74513

RH47300 (e-PCR)
- UniSTS:66582

STS-N93746 (e-PCR)
- UniSTS:39963

RH78354 (e-PCR)
- UniSTS:24096

D10S543 (e-PCR), detects polymorphism
- UniSTS:307

D8S2279 (e-PCR)
- UniSTS:473907

D10S543 (e-PCR), detects polymorphism
- UniSTS:1345

1186 (e-PCR)
- UniSTS:5186

SHGC-108129 (e-PCR)
- UniSTS:170564

RH104052 (e-PCR)
- UniSTS:98377

sY3122 (e-PCR)
- UniSTS:515164

HSC2MD022 (e-PCR)
- UniSTS:60016

D10S2337 (e-PCR)
- UniSTS:33139

ADD3__4199 (e-PCR)
- UniSTS:462713

RH79633 (e-PCR)
- UniSTS:90745

SHGC-33439 (e-PCR)
- UniSTS:36241

RH121559 (e-PCR)
- UniSTS:134300

D10S1199 (e-PCR)
- UniSTS:80028

RH121628 (e-PCR)
- UniSTS:134310

ADD3 (e-PCR)
- UniSTS:502958

STS-AA018233 (e-PCR)
- UniSTS:80823

A008R19 (e-PCR)
- UniSTS:60897

A007G14 (e-PCR)
- UniSTS:17145

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables structural constituent of cytoskeleton	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in condensed nuclear chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gamma-adducin

Names: adducin 3 (gamma); adducin-like protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051033.1 RefSeqGene

Range

16635..144216

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001121.4 → NP_001112.2 gamma-adducin isoform b

See identical proteins and their annotated locations for NP_001112.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1.The encoded isoform (b) is shorter than isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

BC021694, BC057285, BX647403, CF457028

Consensus CDS

CCDS7562.1

UniProtKB/TrEMBL

Q59EK1

Related

ENSP00000277900.8, ENST00000277900.12

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001320591.2 → NP_001307520.1 gamma-adducin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 and 4-6 encode the same isoform (a).

Source sequence(s)

AK223270, BC043143, BC057285, EF553523

Consensus CDS

CCDS7561.1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001320592.2 → NP_001307521.1 gamma-adducin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 and 4-6 encode the same isoform (a).

Source sequence(s)

AK223270, BC043143, BC057285, DA477660, EF553523

Consensus CDS

CCDS7561.1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001320593.2 → NP_001307522.1 gamma-adducin isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 and 4-6 encode the same isoform (a).

Source sequence(s)

AB209810, AK223270, BC043143, DA477660

Consensus CDS

CCDS7561.1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001320594.2 → NP_001307523.1 gamma-adducin isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and initiates translation at a downstream start site compared to variant 1. The encoded isoform (c) has a shorter N-terminus compared to isoform a.

Source sequence(s)

BC021694, BC062559, CN428885, DA700119

UniProtKB/TrEMBL

Q53FL4

Conserved Domains (1) summary

cl00214
Location:59 → 307

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_016824.5 → NP_058432.1 gamma-adducin isoform a

See identical proteins and their annotated locations for NP_058432.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 4-6 encode the same isoform (a).

Source sequence(s)

BC021694, BC057285, BC062559

Consensus CDS

CCDS7561.1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Related

ENSP00000348381.4, ENST00000356080.9

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_019903.5 → NP_063968.1 gamma-adducin isoform b

See identical proteins and their annotated locations for NP_063968.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region compared to variant 1.The encoded isoform (b) is shorter than isoform a. Both variants 2 and 3 encode the same isoform (b).

Source sequence(s)

BC021694, BC057285, CF457028, D67031, DA477660

Consensus CDS

CCDS7562.1

UniProtKB/TrEMBL

Q59EK1

Related

ENSP00000353286.3, ENST00000360162.7

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

109996373..110135565

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047424588.1 → XP_047280544.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q5VU08
XM_047424590.1 → XP_047280546.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q5VU08
XM_047424587.1 → XP_047280543.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q5VU08
XM_024447799.2 → XP_024303567.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_047424595.1 → XP_047280551.1 gamma-adducin isoform X2
XM_024447797.2 → XP_024303565.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447806.2 → XP_024303574.1 gamma-adducin isoform X2

UniProtKB/TrEMBL

Q59EK1

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447803.2 → XP_024303571.1 gamma-adducin isoform X2

UniProtKB/TrEMBL

Q59EK1

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447796.2 → XP_024303564.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447805.2 → XP_024303573.1 gamma-adducin isoform X2

UniProtKB/TrEMBL

Q59EK1

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447801.1 → XP_024303569.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447807.1 → XP_024303575.1 gamma-adducin isoform X2

UniProtKB/TrEMBL

Q59EK1

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447795.1 → XP_024303563.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447804.1 → XP_024303572.1 gamma-adducin isoform X2

UniProtKB/TrEMBL

Q59EK1

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_047424589.1 → XP_047280545.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q5VU08
XM_024447800.2 → XP_024303568.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_047424593.1 → XP_047280549.1 gamma-adducin isoform X2
XM_047424591.1 → XP_047280547.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q5VU08
XM_047424594.1 → XP_047280550.1 gamma-adducin isoform X2
XM_024447794.2 → XP_024303562.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_024447798.1 → XP_024303566.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_047424592.1 → XP_047280548.1 gamma-adducin isoform X2
XM_024447802.2 → XP_024303570.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

D3DRA8, O43243, Q5VU09, Q92773, Q9UEY7, Q9UEY8

UniProtKB/TrEMBL

Q59EK1, Q5VU08

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_047424597.1 → XP_047280553.1 gamma-adducin isoform X3