Bcl2a1a B cell leukemia/lymphoma 2 related protein A1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl2a1aprovided by MGI
Official Full Name: B cell leukemia/lymphoma 2 related protein A1aprovided by MGI
Primary source: MGI:MGI:102687
See related: Ensembl:ENSMUSG00000102037 AllianceGenome:MGI:102687
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A1; Bfl-1; Hbpa1; Bcl2a1
Summary: Predicted to enable BH domain binding activity and channel activity. Involved in negative regulation of apoptotic process. Acts upstream of or within B cell homeostasis and negative regulation of B cell apoptotic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrial outer membrane. Is expressed in several structures, including bone; central nervous system; heart; hemolymphoid system; and respiratory system. Orthologous to human BCL2A1 (BCL2 related protein A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 7.1), thymus adult (RPKM 4.6) and 13 other tissues See more
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Genomic context

Location:: 9 E3.1; 9 47.24 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (88838973..88844469)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (88956920..88962416)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-XL in a murine cell model of myeloid differentiation.
Title: Contribution of A1 to macrophage survival in cooperation with MCL-1 and BCL-X(L) in a murine cell model of myeloid differentiation.
Social defeat stress enhances the rewarding effects of cocaine through alpha1A adrenoceptors in the medial prefrontal cortex of mice.
Title: Social defeat stress enhances the rewarding effects of cocaine through α(1A) adrenoceptors in the medial prefrontal cortex of mice.
The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils.
Title: The pro-survival Bcl-2 family member A1 delays spontaneous and FAS ligand-induced apoptosis of activated neutrophils.
The findings support a model in which survival is determined by quantitative participation of multiple anti-apoptotic proteins, BCL2, Mcl1, and BCL2A1, rather than by a single anti-apoptotic protein.
Title: Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.
This dynamic change in B cell survival mechanisms is unique to Epstein-Barr virus-infected cells and relies on regulation of MCL-1 mitochondrial localization and BFL-1 transcription by the viral EBNA3A protein.
Title: Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.
Loss of A1 alone does not impair T cell-driven immune responses. It therefore appears likely that A1 has critical overlapping functions with other pro-survival BCL-2 proteins in T cell immune responses.
Title: The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.
Overexpression of BCL2A1 in T lymphocytes causes selective impairment of TH17 differentiation and protection against autoimmune arthritis.
Title: Selective Impairment of TH17-Differentiation and Protection against Autoimmune Arthritis after Overexpression of BCL2A1 in T Lymphocytes.
Constitutive expression of the anti-apoptotic molecule Bfl1 (A1) in murine vascular Endothelial Cells leads to prolonged allograft survival due to modifying inflammation.
Title: Constitutive expression of the anti-apoptotic Bcl-2 family member A1 in murine endothelial cells leads to transplant tolerance.
Findings identify BCL2A/A1 as a MYC target that can be induced prematurely during B cell development to aid expansion of otherwise cell-death-prone MYC transgenic pre-B cells
Title: MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis.
Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.
Title: Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493091

U23778 (e-PCR)
- UniSTS:159905

BB218357 (e-PCR)
- UniSTS:185801

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables BH domain binding	ISO Inferred from Sequence Orthology more info
enables channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within B cell homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fusion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bcl-2-related protein A1

Names: A1-A; hemopoietic-specific early response protein; protein BFL-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.