Cd24a CD24a antigen [ Mus musculus (house mouse) ]

Gene ID: 12484, updated on 27-Nov-2024

Summary

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Official Symbol: Cd24aprovided by MGI
Official Full Name: CD24a antigenprovided by MGI
Primary source: MGI:MGI:88323
See related: Ensembl:ENSMUSG00000047139 AllianceGenome:MGI:88323
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HSA; Cd24; Ly-52; nectadrin
Summary: Enables Hsp70 protein binding activity; Hsp90 protein binding activity; and carbohydrate binding activity. Involved in several processes, including chemokine receptor transport out of membrane raft; negative regulation of cytokine production; and regulation of inflammatory response to wounding. Acts upstream of or within several processes, including positive regulation of immune response; regulation of cell-cell adhesion; and regulation of lymphocyte activation. Located in several cellular components, including cell projection membrane; external side of plasma membrane; and membrane raft. Is expressed in several structures, including extraembryonic component; forebrain; genitourinary system; hemolymphoid system; and retina. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human CD24 (CD24 molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14.5 (RPKM 694.7), liver E14 (RPKM 640.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

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See Cd24a in Genome Data Viewer

Location:: 10 B2; 10 23.01 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (43454433..43460261)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (43579169..43584265)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Unraveling the role of CD24 in Hepatocellular carcinoma: Involvement of inactivated Hippo signaling and SOX4-mediated regulation.
Title: Unraveling the role of CD24 in Hepatocellular carcinoma: Involvement of inactivated Hippo signaling and SOX4-mediated regulation.
Dendritic cell expression of CD24 contributes to optimal priming of T lymphocytes in lymph nodes.
Title: Dendritic cell expression of CD24 contributes to optimal priming of T lymphocytes in lymph nodes.
Cancer-associated fibroblasts promoted self-renewal, chemotherapy resistance, metastasis, and tumorigenicity of CD24+ hepatocellular carcinoma cells.
Title: Cancer-associated fibroblasts promote the stemness of CD24(+) liver cells via paracrine signaling.
this study shows that CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-gamma production by CD4(+) T cells
Title: CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-γ production by CD4(+) T cells.
CD24 regulates lipid accumulation but not glucose uptake in 3T3-L1 adipocytes. CD24 regulates gene expression in differentiating adipocytes in vitro in a depot specific manner.
Title: CD24 is required for regulating gene expression, but not glucose uptake, during adipogenesis.
CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities.
Title: CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities.
CD24 has a role in determining the epithelial phenotype of pancreatic cancer
Title: Membranous CD24 drives the epithelial phenotype of pancreatic cancer.
While no obvious role was found for CD24 in the normal development and maintenance of the dopaminergic nigrostriatal system in mice, it may have a role in mediating the neuroprotective aspects of GDNF in this system.
Title: CD24 expression does not affect dopamine neuronal survival in a mouse model of Parkinson's disease.
CD24 cell surface expression may serve as a valuable biomarker in order to identify mammary tumors that will positively respond to targeted IGF1R therapies.
Title: CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy.
mice negative or positive for CD24 did not differ in terms of tumor initiation and burden in 3 mammary and prostate tumor models tested, except for Apc1572T/+ mice, in which lack of CD24 reduced the mammary tumor burden slightly but significantly.
Title: CD24 Is Not Required for Tumor Initiation and Growth in Murine Breast and Prostate Cancer Models.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8)
Targeted (2) 1 citation

General gene information

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Markers

Cd24a (e-PCR), detects polymorphism
- UniSTS:532226

D10Mit107 (e-PCR), detects polymorphism
- UniSTS:126003

PMC123054P3 (e-PCR)
- UniSTS:270432

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Hsp70 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein tyrosine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in B cell receptor transport into membrane raft	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor transport into membrane raft	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of T cell homeostatic proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic mitochondrial changes	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic nuclear changes	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell activation	ISO Inferred from Sequence Orthology more info
involved_in cell activation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in chemokine receptor transport out of membrane raft	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glomerular parietal epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in glomerular parietal epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within homotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of integrin activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of T cell homeostatic proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of erythrocyte aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of erythrocyte clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response to wounding	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of monocyte chemotactic protein-1 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transforming growth factor beta3 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta3 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in podocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in podocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of B cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of T cell homeostatic proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell mediated immune response to tumor cell	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activated T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within positive regulation of inflammatory response to antigenic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of integrin activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of integrin activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within pre-B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell-cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokine-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in respiratory burst	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to estrogen	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in microvillus membrane	IDA Inferred from Direct Assay more info	PubMed
located_in motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: signal transducer CD24

Names: M1/69-J11D heat stable antigen; R13-Ag; X62 heat stable antigen; cluster of differentiation 24; heat stable antigen; lymphocyte antigen 52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428380.1 → NP_001415309.1 signal transducer CD24 isoform 1

Status: VALIDATED

Source sequence(s)

AC159462

UniProtKB/TrEMBL

A0A1L1SQ70
NM_009846.3 → NP_033976.1 signal transducer CD24 isoform 2 precursor

See identical proteins and their annotated locations for NP_033976.1

Status: VALIDATED

Source sequence(s)

AC159462

Consensus CDS

CCDS23821.1

UniProtKB/Swiss-Prot

P24807, P26691

UniProtKB/TrEMBL

Q3THW4, Q8CEU3

Related

ENSMUSP00000057983.9, ENSMUST00000058714.10

Conserved Domains (1) summary

pfam14984
Location:26 → 63

CD24; CD24 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

43454433..43460261

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155569.1 → XP_036011462.1 signal transducer CD24 isoform X1

UniProtKB/Swiss-Prot

P24807, P26691

UniProtKB/TrEMBL

Q3THW4, Q8CEU3

Conserved Domains (1) summary

pfam14984
Location:26 → 63

CD24; CD24 protein