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INO80C INO80 complex subunit C [ Homo sapiens (human) ]

Gene ID: 125476, updated on 27-Nov-2024

Summary

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Official Symbol
INO80Cprovided by HGNC
Official Full Name
INO80 complex subunit Cprovided by HGNC
Primary source
HGNC:HGNC:26994
See related
Ensembl:ENSG00000153391 AllianceGenome:HGNC:26994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IES6; hIes6; C18orf37
Summary
Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Part of Ino80 complex and MLL1 complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 20.7), esophagus (RPKM 7.5) and 24 other tissues See more
Orthologs
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Genomic context

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See INO80C in Genome Data Viewer
Location:
18q12.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (35468333..35497960, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (35659720..35689378, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (33048297..33077924, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:33037967-33038794 Neighboring gene ZNF24 transcription regulator Neighboring gene GATA motif-containing MPRA enhancer 294 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr18:33058203-33059402 Neighboring gene Sharpr-MPRA regulatory region 729 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:33069875-33070595 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:33070661-33071322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:33071323-33071984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13226 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:33083620-33083814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:33088818-33089400 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13228 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13229 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 1 Neighboring gene microRNA 3975 Neighboring gene uncharacterized LOC105372065 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:33251128-33251300

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers. Yau EH, et al. Cancer Res, 2017 Nov 15. PMID 28954733, Free PMC Article
  2. The mammalian INO80 chromatin remodeling complex is required for replication stress recovery. Vassileva I, et al. Nucleic Acids Res, 2014 Aug. PMID 25016522, Free PMC Article
  3. INO80 is required for oncogenic transcription and tumor growth in non-small cell lung cancer. Zhang S, et al. Oncogene, 2017 Mar. PMID 27641337, Free PMC Article
  4. Negative Regulation of p21Waf1/Cip1 by Human INO80 Chromatin Remodeling Complex Is Implicated in Cell Cycle Phase G2/M Arrest and Abnormal Chromosome Stability. Cao L, et al. PLoS One, 2015. PMID 26340092, Free PMC Article
  5. YY1 functions with INO80 to activate transcription. Cai Y, et al. Nat Struct Mol Biol, 2007 Sep. PMID 17721549

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38183

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA strand elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
INO80 complex subunit C
Names
IES6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098817.2 → NP_001092287.1  INO80 complex subunit C isoform 1

    See identical proteins and their annotated locations for NP_001092287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BF475320, BM758571, BQ887287, BY800049
    Consensus CDS
    CCDS45853.1
    UniProtKB/Swiss-Prot
    Q6PI98
    Related
    ENSP00000391457.1, ENST00000441607.6
    Conserved Domains (1) summary
    cl02154
    Location:103 → 223
    YL1_C; YL1 nuclear protein C-terminal domain

  2. NM_001308064.2 → NP_001294993.1  INO80 complex subunit C isoform 3

    See identical proteins and their annotated locations for NP_001294993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' structure, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to isoform 1. The resulting protein (isoform 3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BF475320, BQ441485
    Consensus CDS
    CCDS77177.1
    UniProtKB/TrEMBL
    K7EIY8
    Related
    ENSP00000464948.1, ENST00000586489.5
    Conserved Domains (1) summary
    cl02154
    Location:12 → 132
    YL1_C; YL1 nuclear protein C-terminal domain

  3. NM_194281.4 → NP_919257.2  INO80 complex subunit C isoform 2

    See identical proteins and their annotated locations for NP_919257.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BF475320, BQ887287
    Consensus CDS
    CCDS11914.1
    UniProtKB/Swiss-Prot
    B4DUI4, E9PCS7, Q6PI98, Q86WR1, Q8N994
    Related
    ENSP00000334473.6, ENST00000334598.12
    Conserved Domains (1) summary
    cl02154
    Location:67 → 187
    YL1_C; YL1 nuclear protein C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    35468333..35497960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258196.6 → XP_005258253.1  INO80 complex subunit C isoform X2

    See identical proteins and their annotated locations for XP_005258253.1

    UniProtKB/TrEMBL
    K7EIY8
    Conserved Domains (1) summary
    cl02154
    Location:12 → 132
    YL1_C; YL1 nuclear protein C-terminal domain

  2. XM_011525812.4 → XP_011524114.1  INO80 complex subunit C isoform X1

    Conserved Domains (1) summary
    cl02154
    Location:41 → 161
    YL1_C; YL1 nuclear protein C-terminal domain

  3. XM_017025549.2 → XP_016881038.1  INO80 complex subunit C isoform X2

    UniProtKB/TrEMBL
    K7EIY8
    Conserved Domains (1) summary
    cl02154
    Location:12 → 132
    YL1_C; YL1 nuclear protein C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    35659720..35689378 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318192.1 → XP_054174167.1  INO80 complex subunit C isoform X1

  2. XM_054318193.1 → XP_054174168.1  INO80 complex subunit C isoform X2

    UniProtKB/TrEMBL
    K7EIY8

  3. XM_054318194.1 → XP_054174169.1  INO80 complex subunit C isoform X2

    UniProtKB/TrEMBL
    K7EIY8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PI98.1 GenPept UniProtKB/Swiss-Prot:Q6PI98

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