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LOC126653378 BRD4-independent group 4 enhancer GRCh37_chr21:42308234-42309433 [ Homo sapiens (human) ]

Gene ID: 126653378, updated on 12-Sep-2024

Summary

Gene symbol
LOC126653378
Gene description
BRD4-independent group 4 enhancer GRCh37_chr21:42308234-42309433
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Aug 2022]
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Genomic context

See LOC126653378 in Genome Data Viewer
Location:
chromosome: 21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (40936308..40937507)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (39324758..39325957)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (42308234..42309433)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene DS cell adhesion molecule Neighboring gene uncharacterized LOC124905066 Neighboring gene NANOG hESC enhancer GRCh37_chr21:42241274-42241775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42296237-42296738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42296739-42297238 Neighboring gene NANOG hESC enhancer GRCh37_chr21:42306817-42307318 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:42326589-42327160 Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:42331949-42332650 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:42339602-42340102 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:42424381-42425580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:42474333-42474833 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:42513074-42513270 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr21:42519321-42519905 Neighboring gene long intergenic non-protein coding RNA 323 Neighboring gene microRNA 3197

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_081871.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    40936308..40937507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    39324758..39325957
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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