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LOC126807412 BRD4-independent group 4 enhancer GRCh37_chr5:65813935-65815134 [ Homo sapiens (human) ]

Gene ID: 126807412, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126807412
Gene description
BRD4-independent group 4 enhancer GRCh37_chr5:65813935-65815134
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126807412 in Genome Data Viewer
Location:
chromosome: 5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (66518107..66519306)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (67339694..67340893)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (65813935..65815134)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22618 Neighboring gene uncharacterized LOC105379002 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:65806587-65807786 Neighboring gene long intergenic non-protein coding RNA 2229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16067 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22621 Neighboring gene peptidylprolyl isomerase A pseudogene 78 Neighboring gene microtubule associated serine/threonine kinase family member 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22622 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:66075742-66076941 Neighboring gene NANOG hESC enhancer GRCh37_chr5:66125559-66126060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16068 Neighboring gene NANOG hESC enhancer GRCh37_chr5:66137580-66138081 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:66145039-66146238 Neighboring gene Sharpr-MPRA regulatory region 1390 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:66199778-66200630 Neighboring gene Sharpr-MPRA regulatory region 14441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16069 Neighboring gene MAST4 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_083726.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    66518107..66519306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    67339694..67340893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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