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LOC126861302 BRD4-independent group 4 enhancer GRCh37_chr11:95092304-95093503 [ Homo sapiens (human) ]

Gene ID: 126861302, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126861302
Gene description
BRD4-independent group 4 enhancer GRCh37_chr11:95092304-95093503
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861302 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (95359140..95360339)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (95366295..95367494)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (95092304..95093503)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94883489-94884030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:94884031-94884572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3847 Neighboring gene lncRNA imatinib upregulated Neighboring gene sestrin 3 Neighboring gene uncharacterized LOC100129203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3849 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94964745-94965384 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:94965385-94966024 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:94981794-94982294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5416 Neighboring gene Sharpr-MPRA regulatory region 282 Neighboring gene VISTA enhancer hs2531 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:95074595-95075094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:95180437-95180967 Neighboring gene uncharacterized LOC105369439 Neighboring gene MPRA-validated peak1408 silencer Neighboring gene NANOG hESC enhancer GRCh37_chr11:95209557-95210058 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:95215468-95216018 Neighboring gene uncharacterized LOC105369440

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085801.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    95359140..95360339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    95366295..95367494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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