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LOC126861369 MED14-independent group 3 enhancer GRCh37_chr11:122050835-122052034 [ Homo sapiens (human) ]

Gene ID: 126861369, updated on 12-Sep-2024

Summary

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Gene symbol
LOC126861369
Gene description
MED14-independent group 3 enhancer GRCh37_chr11:122050835-122052034
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

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See LOC126861369 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (122180127..122181326)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (122209100..122210299)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (122050835..122052034)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mir-100-let-7a-2-mir-125b-1 cluster host gene Neighboring gene microRNA 10526 Neighboring gene microRNA 100 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:122067486-122068685 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5666 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:122100557-122101387 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:122244306-122244840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4007 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:122292931-122294130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:122312133-122312797 Neighboring gene RNA, U4atac small nuclear 10, pseudogene Neighboring gene RNA, U4atac small nuclear 5, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085868.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    122180127..122181326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    122209100..122210299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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