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LOC126861470 MED14-independent group 3 enhancer GRCh37_chr12:17135721-17136920 [ Homo sapiens (human) ]

Gene ID: 126861470, updated on 12-Sep-2024

Summary

Gene symbol
LOC126861470
Gene description
MED14-independent group 3 enhancer GRCh37_chr12:17135721-17136920
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 3 enhancer that depends on the BRD2, BRD4, P300/CBP and CDK7 cofactors, but it has limited or no dependence on the MED14 core Mediator complex subunit. [provided by RefSeq, Sep 2022]
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Genomic context

See LOC126861470 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (16982787..16983986)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (16860179..16861378)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (17135721..17136920)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene microsomal glutathione S-transferase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr12:16703865-16704366 Neighboring gene VISTA enhancer hs336 Neighboring gene GOT2 pseudogene 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:16757530-16758030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:16762919-16763418 Neighboring gene LIM domain only 3 Neighboring gene VISTA enhancer hs661 Neighboring gene uncharacterized LOC105369677 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 16 Neighboring gene S-phase kinase associated protein 1 pseudogene 2

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_085969.1 

    Range
    101..1300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    16982787..16983986
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    16860179..16861378
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)