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LOC126861884 BRD4-independent group 4 enhancer GRCh37_chr14:21487674-21488873 [ Homo sapiens (human) ]

Gene ID: 126861884, updated on 12-Sep-2024

Summary

Gene symbol
LOC126861884
Gene description
BRD4-independent group 4 enhancer GRCh37_chr14:21487674-21488873
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 4 enhancer that depends on the BRD2, P300/CBP, MED14 and CDK7 cofactors, but it has limited or no dependence on the BRD4 bromodomain protein. [provided by RefSeq, Sep 2022]
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Genomic context

See LOC126861884 in Genome Data Viewer
Location:
chromosome: 14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (21019515..21020714)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (15216918..15218116)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (21487674..21488873)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene methyltransferase like 17 Neighboring gene uncharacterized LOC101929718 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:21464288-21465487 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:21467511-21468710 Neighboring gene solute carrier family 39 member 2 Neighboring gene NDRG family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5576 Neighboring gene microRNA 6717 Neighboring gene tubulin polymerization promoting protein family member 2 Neighboring gene ribonuclease A family member 13 (inactive)

Genomic regions, transcripts, and products

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_086382.1 

    Range
    101..1300
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    21019515..21020714
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    15216918..15218116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)