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LOC127269875 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:107683301-107683832 [ Homo sapiens (human) ]

Gene ID: 127269875, updated on 12-Sep-2024

Summary

Gene symbol
LOC127269875
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:107683301-107683832
Gene type
biological region
Feature type(s)
regulatory: enhancer, silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

See LOC127269875 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (107140679..107141433)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (107178186..107178939)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (107683301..107684055)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378888 Neighboring gene long intergenic non-protein coding RNA 1661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1415 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1417 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1130 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:107707080-107708279 Neighboring gene protein arginine methyltransferase 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1131 Neighboring gene netrin G1 Neighboring gene NANOG hESC enhancer GRCh37_chr1:107963104-107963605 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:107974475-107975331 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1132 Neighboring gene NDUFA4 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1420 Neighboring gene vav guanine nucleotide exchange factor 3 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:108409832-108410528 Neighboring gene microRNA 7852

Genomic regions, transcripts, and products

General gene information

Other Names

  • ATAC-STARR-seq lymphoblastoid silent region 1129

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_091735.2 

    Range
    101..855
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    107140679..107141433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    107178186..107178939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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