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LOC127269993 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113385908-113386857 [ Homo sapiens (human) ]

Gene ID: 127269993, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127269993
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113385908-113386857
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127269993 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (112843286..112844235)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (112855843..112856792)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113385908..113386857)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1205 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:113266466-113266670 Neighboring gene TAFA chemokine like family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113301747-113302645 Neighboring gene nuclear transport factor 2 pseudogene 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113305483-113306110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:113334060-113334634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113334635-113335207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113345268-113345768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:113345769-113346269 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1206 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113351775-113352296 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:113360077-113360808 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113360809-113361538 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113363733-113364462 Neighboring gene long intergenic non-protein coding RNA 1356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113388166-113388800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113388801-113389435 Neighboring gene long intergenic non-protein coding RNA 1357 Neighboring gene uncharacterized LOC105378911 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113407421-113407930 Neighboring gene MPRA-validated peak371 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:113408443-113408952 Neighboring gene Sharpr-MPRA regulatory region 5001 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:113420877-113421474 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:113423468-113424388 Neighboring gene microRNA 11399

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_091853.1 

    Range
    101..1050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    112843286..112844235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    112855843..112856792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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