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LOC127271432 H3K27ac hESC enhancer GRCh37_chr1:208416769-208417268 [ Homo sapiens (human) ]

Gene ID: 127271432, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127271432
Gene description
H3K27ac hESC enhancer GRCh37_chr1:208416769-208417268
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive human embryonic stem cells. This enhancer is marked by the H3K27ac histone modification. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127271432 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (208243424..208243923)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (207490150..207490649)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (208416769..208417268)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene plexin A2 Neighboring gene uncharacterized LOC124904500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208332738-208333250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208333251-208333761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208347975-208348475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208352531-208353087 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:208353211-208354164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:208371351-208371856 Neighboring gene Sharpr-MPRA regulatory region 4965 Neighboring gene uncharacterized LOC105372884 Neighboring gene Sharpr-MPRA regulatory region 12529 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:208416267-208416768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1777 Neighboring gene uncharacterized LOC105372889 Neighboring gene uncharacterized LOC124904501 Neighboring gene NANOG hESC enhancer GRCh37_chr1:208443936-208444517 Neighboring gene MPRA-validated peak670 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:208547462-208548227 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:208551780-208552116 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:208586461-208586653 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1772 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1780 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_1801 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:208618537-208619736 Neighboring gene uncharacterized LOC107985460

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_093284.1 

    Range
    101..600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    208243424..208243923
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    207490150..207490649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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