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LOC127397511 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50396255-50397145 [ Homo sapiens (human) ]

Gene ID: 127397511, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127397511
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50396255-50397145
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region includes an enhancer that was validated by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in primed human embryonic stem cells, where it is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC127397511 in Genome Data Viewer
Location:
chromosome: 3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (50358824..50359740)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (50388547..50389463)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50396255..50397171)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19905 Neighboring gene CYB561D2-LOC101928965 Neighboring gene cytochrome b561 family member D2 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr3:50401999-50402580 and GRCh37_chr3:50402581-50403164 Neighboring gene uncharacterized LOC101928965 Neighboring gene transmembrane protein 115 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:50408702-50409233 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_70577 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_70587 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50425193-50425797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50425798-50426402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50426403-50427007 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50431709-50432264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50432265-50432820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50432821-50433375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50437650-50438150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50438151-50438651 Neighboring gene MPRA-validated peak4651 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50449343-50449842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:50455687-50456623 Neighboring gene RNA, 5S ribosomal pseudogene 131

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • ATAC-STARR-seq lymphoblastoid active region 19906

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_099480.2 

    Range
    101..1017
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    50358824..50359740
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    50388547..50389463
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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