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LOC127399942 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3761649-3762182 [ Homo sapiens (human) ]

Gene ID: 127399942, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127399942
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3761649-3762182
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127399942 in Genome Data Viewer
Location:
chromosome: 4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (3759922..3760455)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (3758810..3759343)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3761649..3762182)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3662253-3662897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3672069-3672570 Neighboring gene Sharpr-MPRA regulatory region 9480 Neighboring gene long intergenic non-protein coding RNA 2171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3685363-3685922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3685923-3686480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3704600-3705507 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3705508-3706414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3715277-3715778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3715779-3716278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3722956-3723456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3723457-3723957 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3725286-3726088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3726892-3727693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3730463-3731202 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:3747634-3748833 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3748853-3749023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3750933-3751433 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:3756063-3757262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3762717-3763250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3763251-3763784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3769817-3770334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3770527-3771212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3771899-3772584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3772585-3773270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3774643-3775328 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3775329-3776013 Neighboring gene adrenoceptor alpha 2C Neighboring gene uncharacterized LOC124900651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3782589-3783221

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_101906.1 

    Range
    101..634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    3759922..3760455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    3758810..3759343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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