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LOC127407433 OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:147759841-147760442 [ Homo sapiens (human) ]

Gene ID: 127407433, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127407433
Gene description
OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:147759841-147760442
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127407433 in Genome Data Viewer
Location:
chromosome: 6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (147438705..147439306)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (148631991..148632592)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (147759841..147760442)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene STXBP5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17649 Neighboring gene syntaxin binding protein 5 Neighboring gene MPRA-validated peak6197 silencer Neighboring gene MPRA-validated peak6199 silencer Neighboring gene MPRA-validated peak6200 silencer Neighboring gene uncharacterized LOC124901421 Neighboring gene uncharacterized LOC105378043 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:147760443-147761044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:147769071-147769837 Neighboring gene YAP1 pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:147824689-147825218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17650 Neighboring gene MPRA-validated peak6202 silencer Neighboring gene sterile alpha motif domain containing 5 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90808 Neighboring gene MPRA-validated peak6203 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:148037044-148037544 Neighboring gene uncharacterized LOC105378044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:148225800-148226300 Neighboring gene uncharacterized LOC124901423

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_109403.1 

    Range
    101..702
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    147438705..147439306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    148631991..148632592
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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