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LOC127458713 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12302867-12303469 [ Homo sapiens (human) ]

Gene ID: 127458713, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127458713
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12302867-12303469
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127458713 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (12445358..12445960)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (12724941..12725543)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (12302867..12303469)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12283742-12284386 Neighboring gene ALG1 like 12, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:12292881-12293524 Neighboring gene Sharpr-MPRA regulatory regions 5244/11724 and 13137 Neighboring gene family with sequence similarity 86 member B2 Neighboring gene FAM86B2 divergent transcript Neighboring gene defensin beta 109E (pseudogene) Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 7 pseudogene 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12338855-12339594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12344744-12345435 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12354567-12355426 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12355427-12356286 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:12358763-12359264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:12368735-12369234 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:12380441-12380940 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:12382083-12382620 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:12383331-12384025 Neighboring gene NANOG hESC enhancer GRCh37_chr8:12388844-12389380 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:12394565-12395190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12396623-12397488 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:12400676-12401176 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:12401177-12401677 Neighboring gene uncharacterized LOC729732 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:12404893-12405684 Neighboring gene RPS3A pseudogene 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_113482.1 

    Range
    101..703
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    12445358..12445960
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654717.1 Reference GRCh38.p14 PATCHES

    Range
    5640641..5641243
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    12724941..12725543
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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