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LOC127460518 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142048571-142049195 [ Homo sapiens (human) ]

Gene ID: 127460518, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127460518
Gene description
H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142048571-142049195
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC127460518 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141038472..141039096)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142158568..142159192)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142048571..142049195)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142033039-142033749 Neighboring gene uncharacterized LOC105375783 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:142036197-142037048 and GRCh37_chr8:142037049-142037899 Neighboring gene uncharacterized LOC124902030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047320-142047944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047945-142048570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142051549-142052338 Neighboring gene uncharacterized LOC105375784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142069799-142070496 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:142077205-142077706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142082933-142083432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142083433-142084432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142084444-142085234 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142085235-142086025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28039 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142097256-142097756 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28041 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:142104647-142104880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142105126-142106125 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142114470-142115018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142115019-142115566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28042 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142121985-142122506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142122507-142123026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28043 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142128597-142129165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142137284-142138115 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142138949-142139779 Neighboring gene DENND3 antisense RNA 1 Neighboring gene DENN domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_115287.1 

    Range
    101..725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    141038472..141039096
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    142158568..142159192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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