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Ackr3 atypical chemokine receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 12778, updated on 27-Nov-2024

Summary

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Official Symbol
Ackr3provided by MGI
Official Full Name
atypical chemokine receptor 3provided by MGI
Primary source
MGI:MGI:109562
See related
Ensembl:ENSMUSG00000044337 AllianceGenome:MGI:109562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rdc1; Cxcr7; RDC-1; CXC-R7; CXCR-7; Cmkor1
Summary
Predicted to enable chemokine binding activity; chemokine receptor activity; and scavenger receptor activity. Involved in oculomotor nerve development. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of ERK1 and ERK2 cascade. Predicted to be located in several cellular components, including cell surface; clathrin-coated pit; and endosome. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; heart; and hemolymphoid system. Orthologous to human ACKR3 (atypical chemokine receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in adrenal adult (RPKM 169.3), heart adult (RPKM 116.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Ackr3 in Genome Data Viewer
Location:
1 D; 1 45.28 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (90131702..90143446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (90203980..90215724)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01676 Neighboring gene IQ motif containing with AAA domain 1 Neighboring gene RIKEN cDNA 4930434B07 gene Neighboring gene STARR-seq mESC enhancer starr_01677 Neighboring gene STARR-positive B cell enhancer ABC_E4333 Neighboring gene RIKEN cDNA 2700003A03 gene Neighboring gene predicted gene, 34992 Neighboring gene STARR-seq mESC enhancer starr_01681

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Ikeda Y, et al. Cell, 2013 Dec 5. PMID 24315101, Free PMC Article
  2. Blocking CXCR7-mediated adipose tissue macrophages chemotaxis attenuates insulin resistance and inflammation in obesity. Peng H, et al. Biochem Biophys Res Commun, 2016 Oct 28. PMID 27693695
  3. CXCR7 suppression modulates microglial chemotaxis to ameliorate experimentally-induced autoimmune encephalomyelitis. Bao J, et al. Biochem Biophys Res Commun, 2016 Jan 1. PMID 26607112
  4. Loss of Endothelial CXCR7 Impairs Vascular Homeostasis and Cardiac Remodeling After Myocardial Infarction: Implications for Cardiovascular Drug Discovery. Hao H, et al. Circulation, 2017 Mar 28. PMID 28154007
  5. Induction of Regulatory B-Cells by Mesenchymal Stem Cells is Affected by SDF-1α-CXCR7. Qin Y, et al. Cell Physiol Biochem, 2015. PMID 26303308

See all (148) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve.
    Title: Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve.
  2. ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa.
    Title: ACKR3 in olfactory glia cells shapes the immune defense of the olfactory mucosa.
  3. Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.
    Title: Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring.
  4. CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting beta-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells.
    Title: CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells.
  5. Umbilical cord mesenchymal stem cells overexpressing CXCR7 facilitate treatment of ARDS-associated pulmonary fibrosis via inhibition of Notch/Jag1 mediated by the Wnt/beta-catenin pathway.
    Title: Umbilical cord mesenchymal stem cells overexpressing CXCR7 facilitate treatment of ARDS-associated pulmonary fibrosis via inhibition of Notch/Jag1 mediated by the Wnt/β-catenin pathway.
  6. An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.
    Title: An expression and function analysis of the CXCR4/SDF-1 signalling axis during pituitary gland development.
  7. Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting beta-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis.
    Title: Atypical chemokine receptor 3 induces colorectal tumorigenesis in mice by promoting β-arrestin-NOLC1-fibrillarin-dependent rRNA biogenesis.
  8. Histone deacetylase 2 regulates STAT1-dependent upregulation of atypical chemokine receptor 3 to induce M2 macrophage migration and immune escape in hepatocellular carcinoma.
    Title: Histone deacetylase 2 regulates STAT1-dependent upregulation of atypical chemokine receptor 3 to induce M2 macrophage migration and immune escape in hepatocellular carcinoma.
  9. CXCR4 and CXCR7 signaling promotes tumor progression and obesity-associated epithelial-mesenchymal transition in prostate cancer cells.
    Title: CXCR4 and CXCR7 signaling promotes tumor progression and obesity-associated epithelial-mesenchymal transition in prostate cancer cells.
  10. Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium.
    Title: Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium.
Submit: New GeneRIF Correction See all GeneRIFs (80)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (19)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables C-X-C chemokine binding ISO
Inferred from Sequence Orthology
more info
  
enables C-X-C chemokine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables C-X-C chemokine receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables coreceptor activity IEA
Inferred from Electronic Annotation
more info
  
enables scavenger receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables scavenger receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in chemokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
  
involved_in oculomotor nerve development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oculomotor nerve development ISO
Inferred from Sequence Orthology
more info
  
involved_in oculomotor nerve development ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of mesenchymal stem cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mesenchymal stem cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in receptor internalization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vasculogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated pit ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
atypical chemokine receptor 3
Names
C-X-C chemokine receptor type 7
G-protein coupled receptor RDC1 homolog
chemokine (C-X-C motif) receptor 7
chemokine orphan receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271607.1 → NP_001258536.1  atypical chemokine receptor 3

    See identical proteins and their annotated locations for NP_001258536.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC110261, AC120878
    Consensus CDS
    CCDS15152.1
    UniProtKB/Swiss-Prot
    P56485, Q91WI0
    Conserved Domains (1) summary
    cd14987
    Location:45 → 326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_007722.4 → NP_031748.2  atypical chemokine receptor 3

    See identical proteins and their annotated locations for NP_031748.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC110261, AK031100, BQ033958
    Consensus CDS
    CCDS15152.1
    UniProtKB/Swiss-Prot
    P56485, Q91WI0
    Related
    ENSMUSP00000069114.5, ENSMUST00000065587.5
    Conserved Domains (1) summary
    cd14987
    Location:45 → 326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    90131702..90143446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157069.1 → XP_036012962.1  atypical chemokine receptor 3 isoform X1

    UniProtKB/Swiss-Prot
    P56485, Q91WI0
    Conserved Domains (1) summary
    cd14987
    Location:45 → 326
    7tmA_ACKR3_CXCR7; CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56485.2 GenPept UniProtKB/Swiss-Prot:P56485

Gene LinkOut

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