U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC127823890 H3K27ac hESC enhancer GRCh37_chr12:31226445-31226976 [ Homo sapiens (human) ]

Gene ID: 127823890, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
LOC127823890
Gene description
H3K27ac hESC enhancer GRCh37_chr12:31226445-31226976
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive and primed human embryonic stem cells, where it is marked by the H3K27ac histone modification. This locus also includes an accessible chromatin subregion that was validated as an enhancer based on its ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC127823890 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (31073511..31074042)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (30948005..30948536)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31226445..31226976)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902911 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28199 Neighboring gene tetraspanin 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31117766-31118266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31130578-31131412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31133507-31134008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31134009-31134508 Neighboring gene TSPAN11 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31140539-31141040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31141041-31141540 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31165500-31165701 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31181720-31181949 Neighboring gene DDX11 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31227509-31228038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31232984-31233540 Neighboring gene DEAD/H-box helicase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31256969-31257468 Neighboring gene MPRA-validated peak1651 silencer Neighboring gene uncharacterized LOC124902912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31270198-31270728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31270729-31271258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31273911-31274440 Neighboring gene alpha-2-macroglobulin like 1 pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31373729-31374473 Neighboring gene uncharacterized LOC107987168

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • ATAC-STARR-seq lymphoblastoid active region 6162

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_125410.1 

    Range
    101..632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    31073511..31074042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    30948005..30948536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases