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LOC127824489 OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:66890797-66891645 [ Homo sapiens (human) ]

Gene ID: 127824489, updated on 12-Sep-2024

Summary

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Gene symbol
LOC127824489
Gene description
OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:66890797-66891645
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 and NANOG transcription factors and is marked by the H3K27ac histone modification. [provided by RefSeq, Nov 2022]
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Genomic context

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See LOC127824489 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (66497017..66497865)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (66476498..66477346)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (66890797..66891645)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC105369811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:66801605-66802105 Neighboring gene glutamate receptor interacting protein 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:66891646-66892493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6620 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:66978252-66978488 Neighboring gene oxysterol binding protein like 9 pseudogene 4 Neighboring gene oxysterol binding protein like 9 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6621 Neighboring gene NANOG hESC enhancer GRCh37_chr12:67052705-67053206 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4638 Neighboring gene Sharpr-MPRA regulatory region 5579 Neighboring gene VISTA enhancer hs1498 Neighboring gene NANOG hESC enhancer GRCh37_chr12:67175965-67176466 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:67224101-67224271 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:67279097-67279597 Neighboring gene uncharacterized LOC124902956 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_126006.1 

    Range
    101..949
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    66497017..66497865
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    66476498..66477346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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