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LOC127892354 NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59084269-59085128 [ Homo sapiens (human) ]

Gene ID: 127892354, updated on 12-Sep-2024

Summary

Gene symbol
LOC127892354
Gene description
NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59084269-59085128
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay (MPRA) in naive and primed human embryonic stem cells, where it associates with the NANOG transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. This locus also includes two accessible chromatin subregions that were validated as enhancers based on their ability to activate an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) MPRA in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

See LOC127892354 in Genome Data Viewer
Location:
chromosome: 19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58572902..58573761)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61670580..61671439)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (59084269..59085128)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 2A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15210 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59067095-59067778 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11094 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15211 Neighboring gene ubiquitin conjugating enzyme E2 M Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59070738-59071334 Neighboring gene MZF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11096 Neighboring gene myeloid zinc finger 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59083407-59084268 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15214 Neighboring gene CENPB DNA-binding domains containing 2, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:59093108-59093611 Neighboring gene uncharacterized LOC107987272

Genomic regions, transcripts, and products

General gene information

Other Names

  • ATAC-STARR-seq lymphoblastoid active region 15212
  • ATAC-STARR-seq lymphoblastoid active region 15213

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_142164.1 

    Range
    101..960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    58572902..58573761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    61670580..61671439
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)