Plk3 polo like kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plk3provided by MGI
Official Full Name: polo like kinase 3provided by MGI
Primary source: MGI:MGI:109604
See related: Ensembl:ENSMUSG00000028680 AllianceGenome:MGI:109604
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cnk; Fnk; PRK; PLK-3
Summary: This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Ubiquitous expression in colon adult (RPKM 33.3), stomach adult (RPKM 16.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D1; 4 53.41 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (116985852..116991244, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (117128655..117133963, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
Title: Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer.
TUBA1A licenses APC/C-mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3.
Title: TUBA1A licenses APC/C-mediated mitotic progression to drive glioblastoma growth by inhibiting PLK3.
Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia-Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response.
Title: Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia-Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response.
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
Title: The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3.
Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression
Title: Polo-Like Kinase 3 Appears Dispensable for Normal Retinal Development Despite Robust Embryonic Expression.
Calcium- and integrin-binding protein 1 is involved in regulating endomitosis, perhaps through its interaction with Plk3
Title: Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.
Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha
Title: Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.
Plk3 as a new player in the regulation of the PI3K/PDK1/Akt signaling axis by phosphorylation and stabilization of PTEN.
Title: Regulation of PTEN stability and activity by Plk3.
The specificity of TTP for promoting the degradation of Plk3 was demonstrated by the unaltered decay of Plk3 mRNA in cell
Title: Stimulation of polo-like kinase 3 mRNA decay by tristetraprolin.
Ectopic expression of the Plk3-kinase domain (Plk3-KD), but not its Polo-box domain or a Plk3-KD mutant, suppressed the nuclear accumulation of HIF-1 alpha induced by nickel or cobalt ions
Title: Polo-like kinase 3 functions as a tumor suppressor and is a negative regulator of hypoxia-inducible factor-1 alpha under hypoxic conditions.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi disassembly	ISO Inferred from Sequence Orthology more info
involved_in Golgi disassembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic microtubule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G1/S transition checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G1/S transition checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to radiation	ISO Inferred from Sequence Orthology more info
involved_in response to radiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in response to reactive oxygen species	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
located_in Golgi stack	ISS Inferred from Sequence or Structural Similarity more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase PLK3

Names: FGF-inducible kinase; cytokine-inducible serine/threonine-protein kinase

NP_001300845.1

EC 2.7.11.21

NP_038835.2

EC 2.7.11.21

XP_036019516.1

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313916.1 → NP_001300845.1 serine/threonine-protein kinase PLK3 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.

Source sequence(s)

AL671866, BC063051

UniProtKB/Swiss-Prot

Q60806, Q60822, Q9R009

Related

ENSMUSP00000120476.2, ENSMUST00000147730.2

Conserved Domains (4) summary

smart00220
Location:63 → 315

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13117
Location:546 → 613

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:445 → 533

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14189
Location:61 → 315

STKc_PLK3; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3
NM_013807.3 → NP_038835.2 serine/threonine-protein kinase PLK3 isoform 1

See identical proteins and their annotated locations for NP_038835.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL671866, BC063051

Consensus CDS

CCDS18529.1

UniProtKB/TrEMBL

Q3U0L5, Q6P571

Related

ENSMUSP00000076130.6, ENSMUST00000076859.12

Conserved Domains (4) summary

smart00220
Location:63 → 315

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13117
Location:563 → 630

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:462 → 550

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14189
Location:61 → 315

STKc_PLK3; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

116985852..116991244 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163623.1 → XP_036019516.1 serine/threonine-protein kinase PLK3 isoform X1

UniProtKB/TrEMBL

I6L9A2

Conserved Domains (1) summary

cl21453
Location:61 → 315

PKc_like; Protein Kinases, catalytic domain