U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mir-2a-2 mir-2a-2 stem loop [ Drosophila melanogaster (fruit fly) ]

Gene ID: 12798016, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
mir-2a-2provided by FlyBase
Official Full Name
mir-2a-2 stem loopprovided by FlyBase
Primary source
FLYBASE:FBgn0262460
Locus tag
Dmel_CR43035
See related
miRBase:MI0000118; AllianceGenome:FB:FBgn0262460
Gene type
ncRNA
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2a-2; CR32966; CR43035; dme-miR-2a; dme-mir-2a-2; Dmel\CR43035; miR-; mir-2; miR-2; MIR-2; mir-2a; miR-2a; MiR-2a; miR-2a-2; miR2; miR2-a; miR2a
Old locus tag
Dmel_CR32966
Summary
Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated gene silencing by inhibition of translation; negative regulation of apoptotic process; and negative regulation of translational initiation. Predicted to be part of RISC complex. Is expressed in embryonic epidermis and embryonic hindgut. [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mir-2a-2 in Genome Data Viewer
Location:
37F2-37F2; 2-54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19569490..19569561, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19569490..19569561, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spitz Neighboring gene mir-2a-1 stem loop Neighboring gene mir-2b-2 stem loop

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Predicting kissing interactions in microRNA-target complex and assessment of microRNA activity. Cao S, et al. Nucleic Acids Res, 2012 May. PMID 22307238, Free PMC Article
  2. Functionally diverse microRNA effector complexes are regulated by extracellular signaling. Wu PH, et al. Mol Cell, 2013 Oct 10. PMID 24055343, Free PMC Article
  3. Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. Zdanowicz A, et al. Mol Cell, 2009 Sep 24. PMID 19782035
  4. Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Thermann R, et al. Nature, 2007 Jun 14. PMID 17507927
  5. Asymmetry in the assembly of the RNAi enzyme complex. Schwarz DS, et al. Cell, 2003 Oct 17. PMID 14567917

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
  • alternate names: miR-2a
  • mir-2a-2-RA; Dmel\mir-2a-2-RA; CR43035-RA; Dmel\CR43035-RA
  • mir-2a-2-RB; Dmel\mir-2a-2-RB; CR43035-RB; Dmel\CR43035-RB
  • mir-2a-2-RM; Dmel\mir-2a-2-RM; CR43035-RM; Dmel\CR43035-RM

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in miRNA-mediated gene silencing by inhibition of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RISC complex IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19569490..19569561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_048005.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials