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mir-bft bereft [ Drosophila melanogaster (fruit fly) ]

Gene ID: 12798161, updated on 9-Dec-2024

Summary

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Official Symbol
mir-bftprovided by FlyBase
Official Full Name
bereftprovided by FlyBase
Primary source
FLYBASE:FBgn0263107
Locus tag
Dmel_CR42938
See related
miRBase:MI0000343; AllianceGenome:FB:FBgn0263107
Gene type
ncRNA
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
263a; bft; CR31863; CR33580; CR42938; dme-miR-263; dme-mir-263a; dme-miR-263a; Dmel\CR42938; lncRNA-bereft; miR-263; mir-263a; miR-263a; miR-263a-5p; miR263a
Old locus tag
Dmel_CR31863; Dmel_CR33580
Summary
Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including intestinal stem cell homeostasis; intracellular water homeostasis; and miRNA-mediated post-transcriptional gene silencing. Is expressed in adult CNS glial cell; adult brain; and interommatidial bristle. Used to study cystic fibrosis and neurodegenerative disease. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mir-bft in Genome Data Viewer
Location:
33B2-33B2; 2-45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11953410..11953503, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11953410..11953503, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Crystallin Neighboring gene long non-coding RNA::CR43314 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene zucchini

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Direct quantification of 3' terminal 2'-O-methylation of small RNAs by RT-qPCR. Wang N, et al. RNA, 2018 Nov. PMID 30076204, Free PMC Article
  2. Drosophila melanogaster as an organism model for studying cystic fibrosis and its major associated microbial infections. Touré H, et al. Infect Immun, 2023 Nov 16. PMID 37847031, Free PMC Article
  3. Fully automated leg tracking of Drosophila neurodegeneration models reveals distinct conserved movement signatures. Wu S, et al. PLoS Biol, 2019 Jun. PMID 31246996, Free PMC Article
  4. miR-263b Controls Circadian Behavior and the Structural Plasticity of Pacemaker Neurons by Regulating the LIM-Only Protein Beadex. Nian X, et al. Cells, 2019 Aug 18. PMID 31426557, Free PMC Article
  5. Drosophila as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system. Kim K, et al. Proc Natl Acad Sci U S A, 2020 May 12. PMID 32345720, Free PMC Article

See all (86) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior in Drosophila.
    Title: MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior in Drosophila.
  2. a glio-protective role for Drosophila mir-263a mediated by its regulation of glutamate receptor levels in glia, is reported.
    Title: A Glio-Protective Role of mir-263a by Tuning Sensitivity to Glutamate.
  3. miR-263a downregulates the expression of epithelial sodium channel (ENaC) subunits in enterocytes (ECs) to maintain osmotic and intestinal stem cell homeostasis.
    Title: miR-263a Regulates ENaC to Maintain Osmotic and Intestinal Stem Cell Homeostasis in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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  • alternate names: mir-263a stem loop; mir-263a; miR-263a
  • mir-bft-RA; Dmel\mir-bft-RA; CR42938-RA; Dmel\CR42938-RA
  • mir-bft-RB; Dmel\mir-bft-RB; CR42938-RB; Dmel\CR42938-RB
  • mir-bft-RM; Dmel\mir-bft-RM; CR42938-RM; Dmel\CR42938-RM

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA base-pairing translational repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in miRNA-mediated post-transcriptional gene silencing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11953410..11953503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. NR_047938.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials