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CG43125 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 12798281, updated on 9-Dec-2024

Summary

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Official Symbol
CG43125provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0262588
Locus tag
Dmel_CG43125
See related
AllianceGenome:FB:FBgn0262588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG43125; SPH250
Summary
Predicted to be involved in innate immune response. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG43125 in Genome Data Viewer
Location:
98C3-98C3; 3-95 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28262735..28263622, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24088457..24089344, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46079 Neighboring gene long non-coding RNA:CR46080 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45041 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Forcing contacts between mitochondria and the endoplasmic reticulum extends lifespan in a Drosophila model of Alzheimer's disease. Garrido-Maraver J, et al. Biol Open, 2020 Jan 14. PMID 31822473, Free PMC Article
  2. Beneficial commensal bacteria promote Drosophila growth by downregulating the expression of peptidoglycan recognition proteins. Gallo M, et al. iScience, 2022 Jun 17. PMID 35601912, Free PMC Article
  3. The evolution of constitutively active humoral immune defenses in Drosophila populations under high parasite pressure. Zhou SO, et al. PLoS Pathog, 2024 Jan. PMID 38206983, Free PMC Article
  4. Inter- and intra-species variation in genome-wide gene expression of Drosophila in response to parasitoid wasp attack. Salazar-Jaramillo L, et al. BMC Genomics, 2017 Apr 27. PMID 28449654, Free PMC Article
  5. Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects. Cao X, et al. Insect Biochem Mol Biol, 2018 Dec. PMID 30367934, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG43125-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    28262735..28263622 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260415.1 → NP_001247344.1  uncharacterized protein Dmel_CG43125 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247344.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7A7
    Conserved Domains (1) summary
    cl21584
    Location:37 → 137
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7A7 A0A0B4K7A7

Gene LinkOut

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