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LOC128316853 OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:90481250-90482236 [ Homo sapiens (human) ]

Gene ID: 128316853, updated on 12-Sep-2024

Summary

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Gene symbol
LOC128316853
Gene description
OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:90481250-90482236
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in naive and primed human embryonic stem cells. This enhancer associates with the OCT4 transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Jan 2023]
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Genomic context

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See LOC128316853 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (90291801..90292787)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (90902004..90902990)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (90481250..90482236, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene immunoglobulin kappa locus Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:90527913-90528424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:90519311-90519810 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:90518809-90519310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:90485521-90486290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:90484749-90485520 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:90482237-90483224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:90480262-90481249 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:90476879-90477408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:90475288-90476036 Neighboring gene uncharacterized LOC101926946 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:90470323-90470902 Neighboring gene immunoglobulin kappa variable 1/OR2-118 (pseudogene) Neighboring gene immunoglobulin kappa variable 1D-8 Neighboring gene immunoglobulin kappa variable 3D-7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_149457.1 

    Range
    101..1087
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    90291801..90292787
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    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187524.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    109736..110722 complement
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    90902004..90902990
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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