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OR6N1 olfactory receptor family 6 subfamily N member 1 [ Homo sapiens (human) ]

Gene ID: 128372, updated on 10-Dec-2024

Summary

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Official Symbol
OR6N1provided by HGNC
Official Full Name
olfactory receptor family 6 subfamily N member 1provided by HGNC
Primary source
HGNC:HGNC:15034
See related
Ensembl:ENSG00000197403 AllianceGenome:HGNC:15034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR1-22
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See OR6N1 in Genome Data Viewer
Location:
1q23.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (158764236..158840396, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (157901319..157977489, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158734026..158741985, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily K member 5 pseudogene Neighboring gene olfactory receptor family 6 subfamily K member 6 Neighboring gene olfactory receptor family 6 subfamily N member 2 Neighboring gene olfactory receptor family 2 subfamily AQ member 1 pseudogene Neighboring gene olfactory receptor family 10 subfamily AA member 1 pseudogene Neighboring gene myeloid cell nuclear differentiation antigen Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:158856217-158856716 Neighboring gene pyrin and HIN domain family member 5, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:158879152-158879652 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:158908087-158909286 Neighboring gene pyrin and HIN domain family member 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:158922455-158923423 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:158928812-158928990

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  2. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  3. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 6N1
Names
olfactory receptor OR1-22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005185.2 → NP_001005185.1  olfactory receptor 6N1

    See identical proteins and their annotated locations for NP_001005185.1

    Status: VALIDATED

    Source sequence(s)
    AL513205
    Consensus CDS
    CCDS30905.1
    UniProtKB/Swiss-Prot
    B2RUT4, Q5VUU8, Q8NGY5, Q96R35
    UniProtKB/TrEMBL
    Q6IFR3
    Related
    ENSP00000493254.1, ENST00000641846.1
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40 → 305
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    158764236..158840396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000325.2 → XP_016855814.1  olfactory receptor 6N1 isoform X1

    UniProtKB/Swiss-Prot
    B2RUT4, Q5VUU8, Q8NGY5, Q96R35
    UniProtKB/TrEMBL
    Q6IFR3
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40 → 305
    7tm_4; Olfactory receptor

  2. XM_017000327.2 → XP_016855816.1  olfactory receptor 6N1 isoform X1

    UniProtKB/Swiss-Prot
    B2RUT4, Q5VUU8, Q8NGY5, Q96R35
    UniProtKB/TrEMBL
    Q6IFR3
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40 → 305
    7tm_4; Olfactory receptor

  3. XM_017000326.2 → XP_016855815.1  olfactory receptor 6N1 isoform X1

    UniProtKB/Swiss-Prot
    B2RUT4, Q5VUU8, Q8NGY5, Q96R35
    UniProtKB/TrEMBL
    Q6IFR3
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:40 → 305
    7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    157901319..157977489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334458.1 → XP_054190433.1  olfactory receptor 6N1 isoform X1

    UniProtKB/Swiss-Prot
    B2RUT4, Q5VUU8, Q8NGY5, Q96R35
    UniProtKB/TrEMBL
    Q6IFR3

  2. XM_054334460.1 → XP_054190435.1  olfactory receptor 6N1 isoform X1

    UniProtKB/Swiss-Prot
    B2RUT4, Q5VUU8, Q8NGY5, Q96R35
    UniProtKB/TrEMBL
    Q6IFR3

  3. XM_054334459.1 → XP_054190434.1  olfactory receptor 6N1 isoform X1

    UniProtKB/Swiss-Prot
    B2RUT4, Q5VUU8, Q8NGY5, Q96R35
    UniProtKB/TrEMBL
    Q6IFR3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGY5.1 GenPept UniProtKB/Swiss-Prot:Q8NGY5

Gene LinkOut

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