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SPATA25 spermatogenesis associated 25 [ Homo sapiens (human) ]

Gene ID: 128497, updated on 4-Jan-2025

Summary

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Official Symbol
SPATA25provided by HGNC
Official Full Name
spermatogenesis associated 25provided by HGNC
Primary source
HGNC:HGNC:16158
See related
Ensembl:ENSG00000149634 MIM:618936; AllianceGenome:HGNC:16158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSG23; C20orf165; dJ337O18.8
Summary
Involved in spermatogenesis. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in testis (RPKM 5.9), ovary (RPKM 2.4) and 22 other tissues See more
Orthologs
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Genomic context

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See SPATA25 in Genome Data Viewer
Location:
20q13.12
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (45886491..45891016, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (47622985..47625152, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (44515130..44516261, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene zinc finger SWIM-type containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44514972-44515472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44515473-44515973 Neighboring gene zinc finger SWIM-type containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44519312-44520021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17954 Neighboring gene neuralized E3 ubiquitin protein ligase 2 Neighboring gene cathepsin A Neighboring gene ReSE screen-validated silencer GRCh37_chr20:44531171-44531366 Neighboring gene phospholipid transfer protein Neighboring gene Sharpr-MPRA regulatory region 14031 Neighboring gene Sharpr-MPRA regulatory region 10402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:44561248-44561940 Neighboring gene pre-mRNA-splicing factor cwc22-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17955 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44562632-44563323 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:44563324-44564014 Neighboring gene phosphorylated CTD interacting factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Developmental expression pattern of a novel gene, TSG23/Tsg23, suggests a role in spermatogenesis. Zhou Y, et al. Mol Hum Reprod, 2009 Apr. PMID 19240080
  2. The DNA sequence and comparative analysis of human chromosome 20. Deloukas P, et al. Nature, 2001 Dec 20-27. PMID 11780052
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
spermatogenesis-associated protein 25
Names
testis-specific gene 23 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080608.4 → NP_542175.1  spermatogenesis-associated protein 25

    See identical proteins and their annotated locations for NP_542175.1

    Status: VALIDATED

    Source sequence(s)
    AL008726, BC039607
    Consensus CDS
    CCDS13383.1
    UniProtKB/Swiss-Prot
    Q9BR10
    Related
    ENSP00000361597.3, ENST00000372519.4
    Conserved Domains (1) summary
    pfam15218
    Location:1 → 221
    SPATA25; Spermatogenesis-associated protein 25

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    45886491..45891016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451826.2 → XP_024307594.1  spermatogenesis-associated protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR10
    Conserved Domains (1) summary
    pfam15218
    Location:1 → 221
    SPATA25; Spermatogenesis-associated protein 25

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    47622985..47625152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322943.1 → XP_054178918.1  spermatogenesis-associated protein 25 isoform X1

    UniProtKB/Swiss-Prot
    Q9BR10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BR10.1 GenPept UniProtKB/Swiss-Prot:Q9BR10

Gene LinkOut

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