U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC128926060 STARR-positive B cell enhancer ABC_E1778 [ Mus musculus (house mouse) ]

Gene ID: 128926060, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Gene symbol
LOC128926060
Gene description
STARR-positive B cell enhancer ABC_E1778
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rr368680
Summary
This genomic region was identified as a putative B cell regulatory element by FAIRE-seq (formaldehyde-assisted isolation of regulatory elements sequencing), and was validated as an enhancer by STARR-seq (self-transcribing active regulatory region sequencing) in lipopolysaccharide-activated mouse splenic B cells. A subregion was identified as a candidate cis-regulatory module (CRM) in developing mouse thymocytes based on a combination of DNase I hypersensitivity and transcription factor binding. That CRM was validated as an active enhancer by high-throughput CapStarr-seq reporter assays showing weak activity in P5424 T cells. [provided by RefSeq, Oct 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See LOC128926060 in Genome Data Viewer
Location:
chromosome: 8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (127224274..127224575)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene TAR RNA binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_23060 Neighboring gene cytochrome c oxidase assembly factor 6 Neighboring gene thymidine kinase 1 pseudogene Neighboring gene predicted gene, 51605 Neighboring gene STARR-positive B cell enhancer mm9_chr8:129053341-129053641 Neighboring gene STARR-seq mESC enhancer starr_23064 Neighboring gene predicted gene, 39286 Neighboring gene STARR-positive B cell enhancer ABC_E6702 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:129108541-129108724 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:129115560-129115713 Neighboring gene STARR-positive B cell enhancer ABC_E6703 Neighboring gene interferon regulatory factor 2 binding protein 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. High-throughput and quantitative assessment of enhancer activity in mammals by CapStarr-seq. Vanhille L, et al. Nat Commun, 2015 Apr 15. PMID 25872643
  2. Gene regulatory networks STARR-ing B cells. Martínez de Paz A, et al. Nat Immunol, 2020 Feb. PMID 31873293, Free PMC Article
  3. Charting the cis-regulome of activated B cells by coupling structural and functional genomics. Chaudhri VK, et al. Nat Immunol, 2020 Feb. PMID 31873292

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Other Names

  • CapStarr-seq enhancer MGSCv37_chr8:129021544-129021727
  • regulatory region 368680

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_151719.2 

    Range
    101..402
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    127224274..127224575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version