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Cpt1a carnitine palmitoyltransferase 1a, liver [ Mus musculus (house mouse) ]

Gene ID: 12894, updated on 27-Nov-2024

Summary

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Official Symbol
Cpt1aprovided by MGI
Official Full Name
carnitine palmitoyltransferase 1a, liverprovided by MGI
Primary source
MGI:MGI:1098296
See related
Ensembl:ENSMUSG00000024900 AllianceGenome:MGI:1098296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPTI; Cpt1; C730027G07
Summary
Enables carnitine O-palmitoyltransferase activity. Predicted to be involved in several processes, including positive regulation of fatty acid beta-oxidation; regulation of insulin secretion; and triglyceride metabolic process. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; central nervous system; integumental system; sensory organ; and urinary system. Used to study carnitine palmitoyltransferase I deficiency. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in kidney adult (RPKM 56.8), adrenal adult (RPKM 53.2) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Cpt1a in Genome Data Viewer
Location:
19 A; 19 3.08 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (3372328..3435735)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (3322326..3385735)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin mu DNA binding protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:3282897-3283006 Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene microRNA 6984 Neighboring gene STARR-seq mESC enhancer starr_45314 Neighboring gene testis expressed metallothionein like Neighboring gene galanin and GMAP prepropeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CPT1a gene expression reverses the inflammatory and anti-phagocytic effect of 7-ketocholesterol in RAW264.7 macrophages. Calle P, et al. Lipids Health Dis, 2019 Dec 10. PMID 31823799, Free PMC Article
  2. Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension. Lee MH, et al. Am J Physiol Lung Cell Mol Physiol, 2022 Sep 1. PMID 35763400, Free PMC Article
  3. A thyroid hormone response unit formed between the promoter and first intron of the carnitine palmitoyltransferase-Ialpha gene mediates the liver-specific induction by thyroid hormone. Jackson-Hayes L, et al. J Biol Chem, 2003 Mar 7. PMID 12493735
  4. Carnitine palmitoyltransferase 1A is essential for decidualization in mice. Li N, et al. Theriogenology, 2022 Jan 15. PMID 34837783
  5. CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair. Yuan Q, et al. Cell Death Dis, 2021 Aug 14. PMID 34392303, Free PMC Article

See all (142) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of CPT1A disrupts the maintenance and regenerative function of muscle stem cells.
    Title: Overexpression of CPT1A disrupts the maintenance and regenerative function of muscle stem cells.
  2. CPT1A-IL-10-mediated macrophage metabolic and phenotypic alterations ameliorate acute lung injury.
    Title: CPT1A-IL-10-mediated macrophage metabolic and phenotypic alterations ameliorate acute lung injury.
  3. Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase-1A-induced lipid metabolism in diabetic nephropathy.
    Title: Augmenter of liver regeneration knockout aggravates tubular ferroptosis and macrophage activation by regulating carnitine palmitoyltransferase-1A-induced lipid metabolism in diabetic nephropathy.
  4. Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function.
    Title: Inhibition of Crif1 protects fatty acid-induced POMC neuron-like cell-line damage by increasing CPT-1 function.
  5. CPT1A Protects Podocytes From Lipotoxicity and Apoptosis In Vitro and Alleviates Diabetic Nephropathy In Vivo.
    Title: CPT1A Protects Podocytes From Lipotoxicity and Apoptosis In Vitro and Alleviates Diabetic Nephropathy In Vivo.
  6. Tubular CPT1A deletion minimally affects aging and chronic kidney injury.
    Title: Tubular CPT1A deletion minimally affects aging and chronic kidney injury.
  7. ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARalpha- CPT1A axis.
    Title: ACACA reduces lipid accumulation through dual regulation of lipid metabolism and mitochondrial function via AMPK- PPARα- CPT1A axis.
  8. Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice.
    Title: Cpt1a silencing in AgRP neurons improves cognitive and physical capacity and promotes healthy aging in male mice.
  9. CPT1A as a potential therapeutic target for lipopolysaccharide-induced acute lung injury in mice.
    Title: CPT1A as a potential therapeutic target for lipopolysaccharide-induced acute lung injury in mice.
  10. Acidosis attenuates CPT-I-supported bioenergetics as a potential mechanism limiting lipid oxidation.
    Title: Acidosis attenuates CPT-I-supported bioenergetics as a potential mechanism limiting lipid oxidation.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carnitine O-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carnitine O-palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carnitine O-palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carnitine O-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables carnitine O-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in aflatoxin metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carnitine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carnitine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in carnitine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
  
involved_in eating behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in liver regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-chain fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipid storage IEA
Inferred from Electronic Annotation
more info
  
involved_in response to alkaloid IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
  
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
involved_in response to tetrachloromethane IEA
Inferred from Electronic Annotation
more info
  
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
carnitine O-palmitoyltransferase 1, liver isoform
Names
CPT I
CPT1-L
CPTI-L
L-CPT I
carnitine palmitoyltransferase 1, liver
succinyltransferase CPT1A
NP_038523.2
XP_006531717.1
XP_006531721.1
XP_006531722.1
XP_011246904.1
XP_036017309.1
XP_036017310.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013495.2 → NP_038523.2  carnitine O-palmitoyltransferase 1, liver isoform

    See identical proteins and their annotated locations for NP_038523.2

    Status: VALIDATED

    Source sequence(s)
    AK147770, BC054791, CJ081259
    Consensus CDS
    CCDS29395.1
    UniProtKB/Swiss-Prot
    O35288, P97742, Q80SW3, Q8BP98, Q8C7H8
    UniProtKB/TrEMBL
    Q3UGT1, Q7TQD5
    Related
    ENSMUSP00000025835.5, ENSMUST00000025835.6
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    3372328..3435735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248602.4 → XP_011246904.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X2

    UniProtKB/TrEMBL
    Q3UGT1
    Conserved Domains (2) summary
    pfam16484
    Location:26 → 71
    CPT_N; Carnitine O-palmitoyltransferase N-terminus
    pfam00755
    Location:196 → 786
    Carn_acyltransf; Choline/Carnitine o-acyltransferase

  2. XM_036161416.1 → XP_036017309.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

    UniProtKB/Swiss-Prot
    O35288, P97742, Q80SW3, Q8BP98, Q8C7H8
    UniProtKB/TrEMBL
    Q3UGT1, Q7TQD5
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  3. XM_006531654.4 → XP_006531717.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

    See identical proteins and their annotated locations for XP_006531717.1

    UniProtKB/Swiss-Prot
    O35288, P97742, Q80SW3, Q8BP98, Q8C7H8
    UniProtKB/TrEMBL
    Q3UGT1, Q7TQD5
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  4. XM_006531659.2 → XP_006531722.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

    See identical proteins and their annotated locations for XP_006531722.1

    UniProtKB/Swiss-Prot
    O35288, P97742, Q80SW3, Q8BP98, Q8C7H8
    UniProtKB/TrEMBL
    Q3UGT1, Q7TQD5
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  5. XM_036161417.1 → XP_036017310.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X3

    UniProtKB/TrEMBL
    Q3UGT1
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 628
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus

  6. XM_006531658.5 → XP_006531721.1  carnitine O-palmitoyltransferase 1, liver isoform isoform X1

    See identical proteins and their annotated locations for XP_006531721.1

    UniProtKB/Swiss-Prot
    O35288, P97742, Q80SW3, Q8BP98, Q8C7H8
    UniProtKB/TrEMBL
    Q3UGT1, Q7TQD5
    Conserved Domains (2) summary
    pfam00755
    Location:171 → 761
    Carn_acyltransf; Choline/Carnitine o-acyltransferase
    pfam16484
    Location:1 → 47
    CPT_N; Carnitine O-palmitoyltransferase N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97742.4 GenPept UniProtKB/Swiss-Prot:P97742

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