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LOC129660361 ReSE screen-validated silencer GRCh37_chr1:145245299-145245491 [ Homo sapiens (human) ]

Gene ID: 129660361, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129660361
Gene description
ReSE screen-validated silencer GRCh37_chr1:145245299-145245491
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129660361 in Genome Data Viewer
Location:
chromosome: 1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (146192704..146192904)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 (PATCHES) NW_003871055.3 (3008117..3008317)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:145382090-145382818 and GRCh37_chr1:145382819-145383547 Neighboring gene long intergenic non-protein coding RNA 1719 Neighboring gene NBPF member 10 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:145293725-145294226 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:145290760-145290947 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145281548-145282067 Neighboring gene notch 2 N-terminal like A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:145260143-145260725 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145255431-145255931 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:145254930-145255430 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:145239247-145239446 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:145209507-145210007 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:145209006-145209506 Neighboring gene uncharacterized LOC105371254 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:145185134-145185664 Neighboring gene uncharacterized LOC124904401

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_157398.1 

    Range
    101..301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    146192704..146192904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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