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LOC129660786 ReSE screen-validated silencer GRCh37_chr2:109793904-109794078 [ Homo sapiens (human) ]

Gene ID: 129660786, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129660786
Gene description
ReSE screen-validated silencer GRCh37_chr2:109793904-109794078
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129660786 in Genome Data Viewer
Location:
chromosome: 2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (109177448..109177622)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (109637941..109638115)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (109793904..109794078)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RAN binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11854 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11858 Neighboring gene SH3RF3 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16355 Neighboring gene microRNA 4265 Neighboring gene SH3 domain containing ring finger 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11859 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16357 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16361 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:109876451-109876952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:109876953-109877452 Neighboring gene Sharpr-MPRA regulatory region 14332 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:109891529-109891729 Neighboring gene Sharpr-MPRA regulatory region 6940 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 9 Neighboring gene microRNA 4266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_157823.1 

    Range
    101..275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    109177448..109177622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    109637941..109638115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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