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LOC129662716 ReSE screen-validated silencer GRCh37_chr10:71284727-71284879 [ Homo sapiens (human) ]

Gene ID: 129662716, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129662716
Gene description
ReSE screen-validated silencer GRCh37_chr10:71284727-71284879
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129662716 in Genome Data Viewer
Location:
chromosome: 10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (69524971..69525123)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (70393029..70393181)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (71284727..71284879)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71207805-71208306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71209624-71210242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71210243-71210860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71211741-71212241 Neighboring gene tetraspanin 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3493 Neighboring gene Sharpr-MPRA regulatory region 14270 Neighboring gene MPRA-validated peak1006 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2435 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:71287440-71288387 Neighboring gene transmembrane protein 256 pseudogene 1 Neighboring gene uncharacterized LOC105378345 Neighboring gene NANOG hESC enhancer GRCh37_chr10:71329867-71330445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:71331344-71331971 Neighboring gene uncharacterized LOC101929021 Neighboring gene neurogenin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_159725.1 

    Range
    101..253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    69524971..69525123
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    70393029..70393181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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