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LOC129663268 ReSE screen-validated silencer GRCh37_chr12:120803530-120803720 [ Homo sapiens (human) ]

Gene ID: 129663268, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129663268
Gene description
ReSE screen-validated silencer GRCh37_chr12:120803530-120803720
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129663268 in Genome Data Viewer
Location:
chromosome: 12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120365727..120365917)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120352904..120353094)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120803530..120803720)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene sirtuin 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120752165-120752348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120753363-120754138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7139 Neighboring gene RNA, U6 small nuclear 1088, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7140 Neighboring gene phospholipase A2 group IB Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7141 Neighboring gene musashi RNA binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120794238-120794738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120796175-120796787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120796788-120797399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120798696-120799414 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120799415-120800132 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120814267-120814767 Neighboring gene ribosomal protein S27 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7142 Neighboring gene Sharpr-MPRA regulatory region 12947 Neighboring gene MPRA-validated peak2004 silencer Neighboring gene MPRA-validated peak2005 silencer Neighboring gene MPRA-validated peak2007 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120876089-120876610 Neighboring gene uncharacterized LOC124903126 Neighboring gene cytochrome c oxidase subunit 6A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160274.1 

    Range
    101..291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120365727..120365917
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120352904..120353094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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