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LOC129663744 ReSE screen-validated silencer GRCh37_chr16:3781718-3781878 [ Homo sapiens (human) ]

Gene ID: 129663744, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129663744
Gene description
ReSE screen-validated silencer GRCh37_chr16:3781718-3781878
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129663744 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3731717..3731877)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3758974..3759134)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3781718..3781878)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene deoxyribonuclease 1 Neighboring gene uncharacterized LOC124903631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3704869-3705396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3705397-3705924 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3721637-3722136 Neighboring gene uncharacterized LOC124903630 Neighboring gene TNF receptor associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3746221-3746721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3763763-3764271 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7139 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3786759-3787446 Neighboring gene CREB binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10334 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3872073-3872574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3872575-3873074 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3909888-3910072 Neighboring gene DPPA3 pseudogene 6 Neighboring gene Sharpr-MPRA regulatory region 6998 Neighboring gene Sharpr-MPRA regulatory region 1734 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7142 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3930393-3930969 Neighboring gene long intergenic non-protein coding RNA 2861

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160750.1 

    Range
    101..261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3731717..3731877
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3758974..3759134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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