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LOC129663875 ReSE screen-validated silencer GRCh37_chr16:73368016-73368182 [ Homo sapiens (human) ]

Gene ID: 129663875, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129663875
Gene description
ReSE screen-validated silencer GRCh37_chr16:73368016-73368182
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129663875 in Genome Data Viewer
Location:
chromosome: 16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (73334117..73334283)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (79152119..79152285)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (73368016..73368182)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene zinc finger homeobox 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73126852-73127352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73127353-73127853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11103 Neighboring gene HCCAT5-C16orf47 intergenic CAGE-defined high expression enhancer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:73186584-73187107 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73190308-73190808 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73190809-73191309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73204295-73204796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:73204797-73205296 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:73205367-73206216 Neighboring gene hepatocellular carcinoma associated transcript 5 Neighboring gene NANOG hESC enhancer GRCh37_chr16:73230564-73231065 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:73266082-73267281 Neighboring gene uncharacterized LOC124903716 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11105 Neighboring gene VISTA enhancer hs1724 Neighboring gene lncRNA oncogene in head and neck cancer 2 Neighboring gene tRNA-Lys (anticodon TTT) 1-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_160881.1 

    Range
    101..267
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    73334117..73334283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    79152119..79152285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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