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LOC129664184 ReSE screen-validated silencer GRCh37_chr17:80853679-80853938 [ Homo sapiens (human) ]

Gene ID: 129664184, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129664184
Gene description
ReSE screen-validated silencer GRCh37_chr17:80853679-80853938
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in phorbol 12-myristate 13-acetate-treated (for megakaryocytic differentiation) K562 erythroleukemia cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129664184 in Genome Data Viewer
Location:
chromosome: 17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (82895803..82896062)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (83771182..83771441)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (80853679..80853938)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tubulin folding cofactor D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80786629-80787475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80795429-80795930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80802695-80803196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80803197-80803696 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13016 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80807949-80808451 Neighboring gene zinc finger protein 750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80817109-80817884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80824049-80824550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80824551-80825050 Neighboring gene uncharacterized LOC124904096 Neighboring gene TBCD intron CAGE-defined B cell enhancer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:80833329-80834528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80840561-80841358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80842957-80843755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:80856643-80857144 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:80877734-80878933 Neighboring gene uncharacterized LOC124904095 Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr17:80935960-80937159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80942083-80942584 Neighboring gene Sharpr-MPRA regulatory region 7018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80968063-80968585 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:80975436-80976388 Neighboring gene uncharacterized LOC124904094

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_161190.1 

    Range
    101..360
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    82895803..82896062
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    83771182..83771441
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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