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LOC129664827 ReSE screen-validated silencer GRCh37_chr22:25008515-25008883 [ Homo sapiens (human) ]

Gene ID: 129664827, updated on 12-Sep-2024

Summary

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Gene symbol
LOC129664827
Gene description
ReSE screen-validated silencer GRCh37_chr22:25008515-25008883
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region used in a lentiviral ReSE (repressive ability of silencer elements) screen that assays for cell survival based on transcriptional repression of an apoptosis-inducing fusion protein. This region was identified as a functional silencer in HepG2 liver carcinoma cells. [provided by RefSeq, Apr 2023]
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Genomic context

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See LOC129664827 in Genome Data Viewer
Location:
chromosome: 22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (24612548..24612916)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (25073998..25074366)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (25008515..25008883)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905091 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24980432-24980932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24980933-24981433 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24987467-24988460 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24988461-24989453 Neighboring gene leucine rich repeat containing 75B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24990503-24991473 Neighboring gene gamma-glutamyltransferase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24999043-25000008 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:25000009-25000973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:25003664-25004194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:25016763-25017263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:25025816-25026364 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:25026365-25026914 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:25026915-25027462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:25027463-25028012 Neighboring gene BCR pseudogene 3 Neighboring gene POM121 transmembrane nucleoporin like 10, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:25046823-25047590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:25052870-25053379 Neighboring gene ARL5A pseudogene 4 Neighboring gene ACTR2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Systematic identification of silencers in human cells. Pang B, et al. Nat Genet, 2020 Mar. PMID 32094911, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_161864.1 

    Range
    101..469
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    24612548..24612916
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    25073998..25074366
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    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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