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LOC130006388 ATAC-STARR-seq lymphoblastoid silent region 3741 [ Homo sapiens (human) ]

Gene ID: 130006388, updated on 12-Sep-2024

Summary

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Gene symbol
LOC130006388
Gene description
ATAC-STARR-seq lymphoblastoid silent region 3741
Gene type
biological region
Feature type(s)
regulatory: silencer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence represents an accessible chromatin region that was validated as a silencer based on its ability to repress an origin of replication minimal core promoter by the ATAC-STARR-seq (assay for transposase-accessible chromatin with self-transcribing active regulatory region sequencing) massively parallel reporter assay (MPRA) in GM12878 lymphoblastoid cells. [provided by RefSeq, May 2023]
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Genomic context

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See LOC130006388 in Genome Data Viewer
Location:
chromosome: 11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (73376459..73376748)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (73305596..73305885)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73087504..73087793)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3737 Neighboring gene ARHGEF17 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73019433-73020310 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73020316-73021136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73031799-73032452 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73032453-73033105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73033106-73033758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73036372-73037023 Neighboring gene Rho guanine nucleotide exchange factor 17 Neighboring gene Sharpr-MPRA regulatory region 2623 Neighboring gene uncharacterized LOC124902710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73044313-73045026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73061599-73062100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73073093-73073599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5235 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3740 Neighboring gene Sharpr-MPRA regulatory region 2034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5236 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3743 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73097219-73098168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73098169-73099116 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:73099117-73100064 Neighboring gene RELT TNF receptor Neighboring gene family with sequence similarity 168 member A Neighboring gene MPRA-validated peak1349 silencer Neighboring gene MPRA-validated peak1350 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73166211-73166710 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:73205355-73205873 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73205874-73206391 Neighboring gene NANOG hESC enhancer GRCh37_chr11:73262685-73263225 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:73264745-73264969 Neighboring gene Sharpr-MPRA regulatory region 14801 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:73308491-73309219 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 38 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3745 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73336706-73337222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:73337223-73337737 Neighboring gene MIA SH3 domain ER export factor 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ATAC-STARR-seq reveals transcription factor-bound activators and silencers within chromatin-accessible regions of the human genome. Hansen TJ, et al. Genome Res, 2022 Aug 25. PMID 35858748, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_185833.1 

    Range
    101..390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    73376459..73376748
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    73305596..73305885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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