U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CG43346 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 13084069, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
CG43346provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0263051
Locus tag
Dmel_CG43346
See related
AllianceGenome:FB:FBgn0263051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9243; Dmel\CG43346
Old locus tag
Dmel_CG9243
Summary
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in membrane. Predicted to be active in mitochondrion. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 10. Orthologous to human NDUFAF2 (NADH:ubiquinone oxidoreductase complex assembly factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CG43346 in Genome Data Viewer
Location:
39A7-39A7; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21166046..21168581, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21166046..21168581, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Phospholipase D family member 3 Neighboring gene Nibbler Neighboring gene antisense RNA:CR44910 Neighboring gene Nucleolar complex protein 2 Neighboring gene uncharacterized protein Neighboring gene Mitochondrial aconitase 1 Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene uncharacterized protein Neighboring gene burgundy

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A misexpression screen to identify regulators of Drosophila larval hemocyte development. Stofanko M, et al. Genetics, 2008 Sep. PMID 18757933, Free PMC Article
  2. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Bellen HJ, et al. Genetics, 2004 Jun. PMID 15238527, Free PMC Article
  3. A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins. Guichard A, et al. Cell Rep, 2023 Aug 29. PMID 37480566, Free PMC Article
  4. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
  5. Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Sanfilippo P, et al. Genome Biol, 2017 Nov 30. PMID 29191225, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mitochondrial respiratory chain complex I assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial respiratory chain complex I assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein
Names
CG43346-PA
CG43346-PB
CG43346-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21166046..21168581 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299189.1 → NP_001286118.1  uncharacterized protein Dmel_CG43346, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286118.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEW0
    Conserved Domains (1) summary
    cl01534
    Location:31 → 93
    NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12

  2. NM_001259192.2 → NP_001246121.1  uncharacterized protein Dmel_CG43346, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246121.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEW0
    Conserved Domains (1) summary
    cl01534
    Location:31 → 93
    NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12

  3. NM_001259193.1 → NP_001246122.1  uncharacterized protein Dmel_CG43346, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246122.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NEW0
    Conserved Domains (1) summary
    cl01534
    Location:31 → 93
    NDUFA12; NADH ubiquinone oxidoreductase subunit NDUFA12
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NEW0 M9NEW0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.