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Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 [ Mus musculus (house mouse) ]

Gene ID: 13098, updated on 27-Nov-2024

Summary

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Official Symbol
Cyp2c39provided by MGI
Official Full Name
cytochrome P450, family 2, subfamily c, polypeptide 39provided by MGI
Primary source
MGI:MGI:1306818
See related
Ensembl:ENSMUSG00000025003 AllianceGenome:MGI:1306818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CYPIIC39
Summary
Enables arachidonate 11,12-epoxygenase activity. Involved in arachidonate metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; carcinoma (multiple); end stage renal disease; glucose metabolism disease (multiple); and hypertension (multiple). Orthologous to several human genes including CYP2C18 (cytochrome P450 family 2 subfamily C member 18); CYP2C19 (cytochrome P450 family 2 subfamily C member 19); and CYP2C9 (cytochrome P450 family 2 subfamily C member 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward liver adult (RPKM 56.8) See more
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Genomic context

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See Cyp2c39 in Genome Data Viewer
Location:
19 C3; 19 34.15 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (39335790..39558012)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (39347346..39569568)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 53, pseudogene Neighboring gene STARR-seq mESC enhancer starr_46111 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 29 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 72, pseudogene Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 38 Neighboring gene STARR-seq mESC enhancer starr_46112 Neighboring gene STARR-seq mESC enhancer starr_46113 Neighboring gene STARR-seq mESC enhancer starr_46114 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 67 Neighboring gene STARR-seq mESC enhancer starr_46115 Neighboring gene STARR-seq mESC enhancer starr_46116 Neighboring gene cytochrome P450, family 2, subfamily c, polypeptide 68

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice. Andreola F, et al. J Biol Chem, 2004 Jan 30. PMID 14623888
  2. A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies. Meng XY, et al. Biochim Biophys Acta, 2009 Jul. PMID 19358898
  3. Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage. Kawamura T, et al. Biopharm Drug Dispos, 2022 Aug. PMID 35748067
  4. Altered vitamin A homeostasis and increased size and adiposity in the rdh1-null mouse. Zhang M, et al. FASEB J, 2007 Sep. PMID 17435174
  5. Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid. Luo G, et al. Arch Biochem Biophys, 1998 Sep 1. PMID 9721182

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. By comparison of active site architectures between CYP2C38 and CYP2C39, the possible reasons affecting their substrate binding were proposed
    Title: A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies.
  2. CYP2C39 is a novel retinoic acid 4-hydroxylase
    Title: Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate 11,12-epoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arachidonate 14,15-epoxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables arachidonate epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables caffeine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables estrogen 16-alpha-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acid omega-1 hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables retinoic acid 4-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables steroid hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in arachidonate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arachidonate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytochrome P450 2C39
Names
cytochrome P450, 2c39
NP_001360866.1
NP_034133.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001373937.1 → NP_001360866.1  cytochrome P450 2C39 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC117790, AC139233
    UniProtKB/TrEMBL
    Q6PER7
    Conserved Domains (1) summary
    pfam00067
    Location:30 → 487
    p450; Cytochrome P450

  2. NM_010003.2 → NP_034133.2  cytochrome P450 2C39 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034133.2

    Status: VALIDATED

    Source sequence(s)
    AC117790, AC139233
    Consensus CDS
    CCDS29795.1
    UniProtKB/Swiss-Prot
    B9EIA6, G5E854, P56656
    UniProtKB/TrEMBL
    Q6PER7
    Related
    ENSMUSP00000025968.5, ENSMUST00000025968.5
    Conserved Domains (1) summary
    pfam00067
    Location:30 → 487
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    39335790..39558012
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56656.2 GenPept UniProtKB/Swiss-Prot:P56656

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