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Dad1 defender against cell death 1 [ Mus musculus (house mouse) ]

Gene ID: 13135, updated on 27-Nov-2024

Summary

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Official Symbol
Dad1provided by MGI
Official Full Name
defender against cell death 1provided by MGI
Primary source
MGI:MGI:101912
See related
Ensembl:ENSMUSG00000022174 AllianceGenome:MGI:101912
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable enzyme activator activity. Acts upstream of or within blastocyst development and negative regulation of apoptotic process. Predicted to be part of oligosaccharyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 143.6), duodenum adult (RPKM 96.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dad1 in Genome Data Viewer
Location:
14 C2; 14 27.7 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54472942..54491386, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54235485..54253929, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene T cell receptor alpha chain Neighboring gene STARR-positive B cell enhancer ABC_E7311 Neighboring gene CapStarr-seq enhancers MGSCv37_chr14:54846812-54847013 and MGSCv37_chr14:54847102-54847395 Neighboring gene STARR-positive B cell enhancer ABC_E5435 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:54852981-54853251 Neighboring gene STARR-positive B cell enhancer ABC_E1168 Neighboring gene T cell receptor alpha joining 1 Neighboring gene abhydrolase domain containing 4 Neighboring gene olfactory receptor family 6 subfamily E member 1 Neighboring gene T cell receptor alpha constant

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adjacent DNA elements dominantly restrict the ubiquitous activity of a novel chromatin-opening region to specific tissues. Ortiz BD, et al. EMBO J, 1997 Aug 15. PMID 9305645, Free PMC Article
  2. Abnormalities of developmental cell death in Dad1-deficient mice. Nishii K, et al. Genes Cells, 1999 Apr. PMID 10336695
  3. Function and factor interactions of a locus control region element in the mouse T cell receptor-alpha/Dad1 gene locus. Ortiz BD, et al. J Immunol, 2001 Oct 1. PMID 11564801
  4. A highly conserved apoptotic suppressor gene is located near the chicken T-cell receptor alpha chain constant region. Wang K, et al. Immunogenetics, 1997. PMID 9271627
  5. Deletion of Dad1 in mice induces an apoptosis-associated embryonic death. Brewster JL, et al. Genesis, 2000 Apr. PMID 10748466

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
Names
DAD-1
oligosaccharyl transferase subunit DAD1
NP_001106829.1
NP_034145.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113358.1 → NP_001106829.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

    See identical proteins and their annotated locations for NP_001106829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK002446, BC058116, CN833883
    Consensus CDS
    CCDS27084.1
    UniProtKB/Swiss-Prot
    P61804, Q3V3W6
    Related
    ENSMUSP00000022781.8, ENSMUST00000022781.8
    Conserved Domains (1) summary
    pfam02109
    Location:7 → 113
    DAD; DAD family

  2. NM_010015.4 → NP_034145.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

    See identical proteins and their annotated locations for NP_034145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing the 3' terminal non-coding exon found in transcript variant 1, therefore, has a different 3' UTR. Transcript variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK030925, CN833883
    Consensus CDS
    CCDS27084.1
    UniProtKB/Swiss-Prot
    P61804, Q3V3W6
    Related
    ENSMUSP00000122366.2, ENSMUST00000128231.2
    Conserved Domains (1) summary
    pfam02109
    Location:7 → 113
    DAD; DAD family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54472942..54491386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61804.3 GenPept UniProtKB/Swiss-Prot:P61804

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