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TPRA1 transmembrane protein adipocyte associated 1 [ Homo sapiens (human) ]

Gene ID: 131601, updated on 27-Nov-2024

Summary

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Official Symbol
TPRA1provided by HGNC
Official Full Name
transmembrane protein adipocyte associated 1provided by HGNC
Primary source
HGNC:HGNC:30413
See related
Ensembl:ENSG00000163870 MIM:608336; AllianceGenome:HGNC:30413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR175; TPRA40; TMEM227
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within embryonic cleavage and negative regulation of mitotic cell cycle phase transition. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta (RPKM 7.3), endometrium (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

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See TPRA1 in Genome Data Viewer
Location:
3q21.3
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (127571232..127598231, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (130305897..130332949, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (127290075..127317074, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2016 Neighboring gene uncharacterized LOC105374094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127110535-127111346 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127113684-127114550 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:127121540-127122739 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20456 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:127171391-127171911 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127184463-127184964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127184965-127185464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127191951-127192452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127192453-127192952 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:127212327-127213012 Neighboring gene long intergenic non-protein coding RNA 1471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14687 Neighboring gene long intergenic non-protein coding RNA 2034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127293720-127294299 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127294300-127294878 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127298480-127299441 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127307841-127308518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127308519-127309195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:127316932-127317889 Neighboring gene microRNA 6825 Neighboring gene microRNA 7976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127335678-127336178 Neighboring gene uncharacterized LOC107986126 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20458 Neighboring gene minichromosome maintenance complex component 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:127357688-127358188 Neighboring gene podocalyxin like 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:127386638-127386819 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14694 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14695

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels. Singh J, et al. J Biol Chem, 2015 Dec 4. PMID 26451044, Free PMC Article
  2. Differential expression of a novel seven transmembrane domain protein in epididymal fat from aged and diabetic mice. Yang H, et al. Endocrinology, 1999 Jun. PMID 10342878
  3. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library. Büssow K, et al. Nucleic Acids Res, 1998 Nov 1. PMID 9776767, Free PMC Article
  4. Novel interactive partners of neuroligin 3: new aspects for pathogenesis of autism. Shen C, et al. J Mol Neurosci, 2015 May. PMID 25464930
  5. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. Ma J, et al. Atherosclerosis, 2007 Mar. PMID 16806233

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gpr175 is a novel positive regulator of the Hh signaling pathway
    Title: The Orphan G Protein-coupled Receptor Gpr175 (Tpra40) Enhances Hedgehog Signaling by Modulating cAMP Levels.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32197

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic cleavage IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein adipocyte-associated 1
Names
G protein-coupled receptor 175
integral membrane protein GPR175
seven transmembrane domain orphan receptor
transmembrane domain protein regulated in adipocytes 40 kDa
transmembrane protein 227
transmembrane protein, adipocyte asscociated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136053.4 → NP_001129525.1  transmembrane protein adipocyte-associated 1 isoform 1

    See identical proteins and their annotated locations for NP_001129525.1

    Status: VALIDATED

    Source sequence(s)
    AC084035, BC050711, BM670609, HY066741
    Consensus CDS
    CCDS3042.1
    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
    Related
    ENSP00000347748.3, ENST00000355552.8
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 312
    Tmemb_40; Predicted membrane protein

  2. NM_001142646.4 → NP_001136118.1  transmembrane protein adipocyte-associated 1 isoform 2

    See identical proteins and their annotated locations for NP_001136118.1

    Status: VALIDATED

    Source sequence(s)
    AC084035, AF289568, BC050711, BM670609, HY066741
    Consensus CDS
    CCDS46899.1
    UniProtKB/Swiss-Prot
    Q86W33
    Related
    ENSP00000296210.7, ENST00000296210.11
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 203
    Tmemb_40; Predicted membrane protein

  3. NM_001353001.2 → NP_001339930.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC084035, BM670609
    Consensus CDS
    CCDS3042.1
    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 312
    Tmemb_40; Predicted membrane protein

  4. NM_001353002.2 → NP_001339931.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC084035, BM670609, CF132113
    Consensus CDS
    CCDS3042.1
    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 312
    Tmemb_40; Predicted membrane protein

  5. NM_001353003.2 → NP_001339932.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023593, AC084035, BM670609
    Consensus CDS
    CCDS3042.1
    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 312
    Tmemb_40; Predicted membrane protein

  6. NM_001353004.2 → NP_001339933.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023593, AC084035, BM670609
    Consensus CDS
    CCDS3042.1
    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
    Related
    ENSP00000498161.1, ENST00000648957.1
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 312
    Tmemb_40; Predicted membrane protein

  7. NM_001353005.2 → NP_001339934.1  transmembrane protein adipocyte-associated 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC023593, AC084035, BM670609
    Consensus CDS
    CCDS3042.1
    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 312
    Tmemb_40; Predicted membrane protein

  8. NM_001353006.2 → NP_001339935.1  transmembrane protein adipocyte-associated 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC084035, BM670609
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 166
    Tmemb_40; Predicted membrane protein

  9. NM_001353007.2 → NP_001339936.1  transmembrane protein adipocyte-associated 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC023593, AC084035, BM670609
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 275
    Tmemb_40; Predicted membrane protein

RNA

  1. NR_073377.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084035, BC017058, BM670609, HY066741

  2. NR_148226.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC084035, BM670609

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    127571232..127598231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447443.1 → XP_047303399.1  transmembrane protein adipocyte-associated 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

  2. XM_047447440.1 → XP_047303396.1  transmembrane protein adipocyte-associated 1 isoform X1

  3. XM_047447441.1 → XP_047303397.1  transmembrane protein adipocyte-associated 1 isoform X1

  4. XM_047447442.1 → XP_047303398.1  transmembrane protein adipocyte-associated 1 isoform X1

  5. XM_006713496.4 → XP_006713559.1  transmembrane protein adipocyte-associated 1 isoform X2

    See identical proteins and their annotated locations for XP_006713559.1

    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4
    Related
    ENSP00000418298.1, ENST00000489960.5
    Conserved Domains (1) summary
    pfam10160
    Location:39 → 312
    Tmemb_40; Predicted membrane protein

  6. XM_047447444.1 → XP_047303400.1  transmembrane protein adipocyte-associated 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    130305897..130332949 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345229.1 → XP_054201204.1  transmembrane protein adipocyte-associated 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

  2. XM_054345226.1 → XP_054201201.1  transmembrane protein adipocyte-associated 1 isoform X1

  3. XM_054345227.1 → XP_054201202.1  transmembrane protein adipocyte-associated 1 isoform X1

  4. XM_054345228.1 → XP_054201203.1  transmembrane protein adipocyte-associated 1 isoform X1

  5. XM_054345231.1 → XP_054201206.1  transmembrane protein adipocyte-associated 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

  6. XM_054345230.1 → XP_054201205.1  transmembrane protein adipocyte-associated 1 isoform X2

    UniProtKB/Swiss-Prot
    A8MVB8, D3DNA9, Q86W33, Q8WZ24, Q96AJ6, Q9P2R4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016372.2: Suppressed sequence

    Description
    NM_016372.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86W33.1 GenPept UniProtKB/Swiss-Prot:Q86W33

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