Dck deoxycytidine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dckprovided by MGI
Official Full Name: deoxycytidine kinaseprovided by MGI
Primary source: MGI:MGI:102726
See related: Ensembl:ENSMUSG00000029366 AllianceGenome:MGI:102726
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables deoxyadenosine kinase activity. Involved in dAMP salvage. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; integumental system; midbrain; nose; and telencephalon. Orthologous to human DCK (deoxycytidine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 26.6), liver E14.5 (RPKM 23.2) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 E1; 5 43.96 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (88912872..88931136)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (88765013..88783277)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation of a single serine 74 residue has profound effects on murine T and B lymphocyte development, suggesting that post-translational regulation of dCK has a role in maintaining genomic stability during hematopoiesis.
Title: Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance.
activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement and suggests a novel therapeutic target for the treatment of COPD
Title: Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease.
Deoxycytidine kinase is a new regulator of hematopoietic integrity and lymphocyte quiescence and survival.
Title: A deficiency in nucleoside salvage impairs murine lymphocyte development, homeostasis, and survival.
The severe impact of dCK inactivation on lymphopoiesis was unexpected given that nucleoside salvage has been thought to play a limited, "fine-tuning" role in regulating deoxyribonucleotide triphosphate pools produced by the de novo pathway.
Title: Requirement for deoxycytidine kinase in T and B lymphocyte development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (2) 1 citation
Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:437189 (e-PCR)
- UniSTS:157241

Dck (e-PCR), detects polymorphism
- UniSTS:527307

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables cytidine kinase activity	IEA Inferred from Electronic Annotation more info
enables cytidine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxyadenosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables deoxyadenosine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxycytidine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxycytidine kinase activity	ISO Inferred from Sequence Orthology more info
enables deoxycytidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deoxyguanosine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables deoxyribonucleoside binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine deoxyribonucleoside binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dAMP salvage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dGMP salvage	TAS Traceable Author Statement more info	PubMed
involved_in deoxycytidine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyrimidine nucleotide metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: deoxycytidine kinase

Names: deoxyadenosine kinase; deoxyguanosine kinase

NP_031858.1

EC 2.7.1.113

EC 2.7.1.74

EC 2.7.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007832.4 → NP_031858.1 deoxycytidine kinase

See identical proteins and their annotated locations for NP_031858.1

Status: VALIDATED

Source sequence(s)

BC060062, BU052737

Consensus CDS

CCDS19405.1

UniProtKB/Swiss-Prot

P43346

UniProtKB/TrEMBL

Q545E8, Q80US6

Related

ENSMUSP00000031311.10, ENSMUST00000031311.10

Conserved Domains (2) summary

COG0125
Location:24 → 257

Tmk; Thymidylate kinase [Nucleotide transport and metabolism]

pfam01712
Location:24 → 258

dNK; Deoxynucleoside kinase